AI Article Synopsis
Article Abstract
The accurate diagnosis of osteoporosis has gained increasing importance due to the aging of our society. Areal bone mineral density (BMD) measured by dual-energy X-ray absorptiometry (DXA) is an established criterion in the diagnosis of osteoporosis. This measure, however, is limited by its two-dimensionality. This work presents a method to reconstruct both the 3D bone shape and 3D BMD distribution of the proximal femur from a single DXA image used in clinical routine. A statistical model of the combined shape and BMD distribution is presented, together with a method for its construction from a set of quantitative computed tomography (QCT) scans. A reconstruction is acquired in an intensity based 3D-2D registration process whereby an instance of the model is found that maximizes the similarity between its projection and the DXA image. Reconstruction experiments were performed on the DXA images of 30 subjects, with a model constructed from a database of QCT scans of 85 subjects. The accuracy was evaluated by comparing the reconstructions with the same subject QCT scans. The method presented here can potentially improve the diagnosis of osteoporosis and fracture risk assessment from the low radiation dose and low cost DXA devices currently used in clinical routine.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1109/TMI.2011.2163074 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Pregnancy- and lactation-related bone fragility: The hidden risk.
Jt Dis Relat Surg
January 2025
Department of Orthopedics, Harvard Medical School, The Center For Advanced Orthopedic Studies, BIDMC, Boston, MA, 02215 USA.
Pregnancy and lactation significantly alter bone homeostasis, potentially leading to impaired bone quality and mineralization due to the increased metabolic demands of the developing offspring. While most women with osteopenia during these periods experience a return to baseline bone density after weaning, some may remain at risk for fractures, particularly in cancellous bone. There are inconsistencies in current reports on fracture risk and appropriate treatment strategies.
View Article and Find Full Text PDF[Comparative study of two fixation methods in single segment interbody fusion and fixation with unilateral dual channel spinal endoscopic technique].
Zhongguo Gu Shang
December 2024
Shaanxi Provincial People's Hospital, Xi'an 710068, Shaanxi, China.
Objective: To explore clinical efficacy of unilateral and bilateral nail-rod system fixation in single-level intervertebral fusion fixation of lumbar disc herniation (LDH) and instability with unilateral dual-channel spinal endoscopy.
Methods: The clinical data of 63 patients with LDH complicated with instability treated by unilateral double-channel spinal endoscopy from March 2021 to June 2022 were retrospectively analyzed. According to intraoperative fixation methods, the patients were divided into two groups, included unilateral nail rod system fixation group(unilateral group) and bilateral nail rod system fixation group(bilateral group).
Decoding ferroptosis: transforming orthopedic disease management.
Front Pharmacol
December 2024
Orthopedic Center, The Third Affiliated Hospital of Changchun University of Chinese Medicine, Changchun, China.
As a mechanism of cell death, ferroptosis has gained popularity since 2012. The process is distinguished by iron toxicity and phospholipid accumulation, in contrast to autophagy, apoptosis, and other cell death mechanisms. It is implicated in the advancement of multiple diseases across the body.
View Article and Find Full Text PDFDevelopment and validation of a three-dimensional nomogram prediction model for knee osteoarthritis in middle-aged population.
J Orthop Surg Res
December 2024
Teaching and Research Section of Clinical Nursing, Xiangya Hospital of Central South University, 87 Xiangya Road, Kaifu District, Changsha, Hunan Province, China.
Objectives: This study aims to identify predictors of knee osteoarthritis (KOA) risk in middle-aged population, construct and validate a nomogram for KOA in this demographic.
Methods: From June to December 2020, we conducted a cross-sectional survey on 5,527 middle-aged individuals from Changsha and Zhangjiajie cities in Hunan Province, selected using a stratified multi-stage random sampling method. Data collection involved a structured questionnaire encompassing general demographic, physical condition, and lifestyle behaviors dimensions.
[Research progress of novel bone turnover markers in osteoporosis].
Zhonghua Yu Fang Yi Xue Za Zhi
December 2024
Department of Laboratory Medicine, West China Second University Hospital, Sichuan University Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education, Chengdu610041, China.
Bones possess metabolic activity, with their homeostasis maintained by bone resorption and bone formation mediated by osteoclasts and osteoblasts. By measuring bone metabolism markers, the overall state of bone metabolism and dynamic changes in systemic bone tissue can be reflected. Traditional bone turnover markers, including alkaline phosphatase, bonespecific alkaline phosphatase, procollagen type 1 N-terminal propeptide, procollagen type 1 C-terminal propeptide, osteocalcin, c-terminal telopeptides of type 1 collagen(CTX) and its subtype β-CTX, n-terminal telopeptides of type 1 collagen, have been widely used in clinical practice but still have limitations in terms of stability, diagnostic reliability, and specific reflection of bone sites.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!