AI Article Synopsis
- Runs of homozygosity (ROH) are long stretches of similar genetic variations found to be more frequent in unrelated people than expected.
- A study analyzing ROH larger than 1.5 Mb in 5,974 participants from the Rotterdam Study aimed to link these genetic patterns to survival rates.
- The findings indicated that neither ROH nor overall homozygosity percentages had any significant impact on survival into old age over a 12-year follow-up period.
Article Abstract
Runs of homozygosity (ROH) are extended tracts of adjacent homozygous single nucleotide polymorphisms (SNPs) that are more common in unrelated individuals than previously thought. It has been proposed that estimating ROH on a genome-wide level, by making use of the genome-wide single nucleotide polymorphism (SNP) data, will enable to indentify recessive variants underlying complex traits. Here, we examined ROH larger than 1.5 Mb individually and in combination for association with survival in 5974 participants of the Rotterdam Study. In addition, we assessed the role of overall homozygosity, expressed as a percentage of the autosomal genome that is in ROH longer than 1.5 Mb, on survival during a mean follow-up period of 12 years. None of these measures of homozygosity was associated with survival to old age.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3143169 | PMC |
| http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0022580 | PLOS |
Publication Analysis
Top Keywords
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!