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Circulating resistin levels and mutation burden of the RETN gene variants predict long-term mortality in a Taiwanese population.
Sci Rep
January 2025
Department of Research, Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, New Taipei City, Taiwan.
Human resistin is a proinflammatory cytokine involving the development and progression of cancer and cardiovascular diseases. However, prediction of long-term outcome using circulating resistin level and its genetic determinants in a population-based study remain to be explored. After genome-wide association study (GWAS), DNA methylation (DNAm) analysis and functional assays of a RETN rs370006313 variant, we tested whether resistin level and its genetic determinants can be used to determine the long-term outcomes of 5678 Taiwan Biobank (TWB) participants.
View Article and Find Full Text PDFMenopausal age, adipokines, and heart failure incidence in postmenopausal women of the Multi-Ethnic Study of Atherosclerosis.
Menopause
January 2025
Division of Public Health Sciences, Wake Forest University School of Medicine, Winston Salem, NC.
Article Synopsis
- * It involved 746 postmenopausal women and tracked incidents of HF over a median period of 17.8 years, revealing that early menopause significantly increased HF risk, even after accounting for various cardiovascular factors.
- * Adiponectin, one of the adipokines, was found to be independently associated with HF risk, while leptin and resistin showed no significant correlation.
The Trend of Changes in Adiponectin, Resistin, and Adiponectin-Resistin Index Values in Type 2 Diabetic Patients with the Development of Metabolic Syndrome.
Medicina (Kaunas)
November 2024
Department of Human Physiology, Faculty of Medicine, University of Sarajevo, 71000 Sarajevo, Bosnia and Herzegovina.
: This study aimed to investigate the novel adiponectin-resistin (AR) index as a predictor of the development of metabolic syndrome (MetS) in individuals with type 2 diabetes mellitus (T2DM). MetS is common in T2DM and increases cardiovascular risk. Adiponectin and resistin, adipokines with opposing effects on insulin sensitivity and inflammation, make the AR index a potential marker for metabolic risk.
View Article and Find Full Text PDFAntipsychotic-Treated Schizophrenia Patients Develop Inflammatory and Oxidative Responses Independently From Obesity: However, Metabolic Disturbances Arise From Schizophrenia-Related Obesity.
Hum Psychopharmacol
November 2024
Medical Faculty, Departments of Medical Biochemistry, Bursa Uludag Universitiy, Bursa, Turkey.
Objective: To define the impact of obesity on inflammatory and oxidative disturbances in antipsychotic-treated schizophrenia patients.
Methods: Several cytokines, inflammatory, metabolic, and oxidative status markers were evaluated in obese (n = 40) and non-obese (n = 40) antipsychotic-treated patients and compared with age-and BMI-matched controls (n = 80).
Results: Schizophrenia patients had higher leptin, TNF-α, adiponectin, visfatin, resistin, P-selectin, NPY, BDNF, CD40-L, MCP-1, and malondialdehyde, and lower IL-6, ghrelin, neopterin, and vitamin E levels compared to their respective controls (p < 0.
Mediterranean Diet Prior to Ischemic Stroke and Potential Circulating Mediators of Favorable Outcomes.
Nutrients
September 2024
Department of Neurology, Hospital Universitario Central de Asturias (HUCA), 33011 Oviedo, Spain.
. A Mediterranean diet (MD) has been associated with neuroprotective effects. We aimed to assess the MD's association with stroke prognosis and the potential mediators involved.
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