This preliminary study aims to explore how adrenergic agents modulate stress response and affect stress-induced behavioral and brain changes in rodents. A total of 40 adult male Wistar rats were subjected to chronic unpredictable mild stress (CUMS) and randomly divided into five groups. At 30 min before daily stress exposure, the rats were intraperitoneally injected with phentolamine (5mg/kg), noradrenalin (1.0mg/kg), propranolol (10mg/kg), isoproterenol (0.05 mg/kg) or saline, respectively. Another 8 rats served as normal control and received daily saline injection without stress exposure. Open-field behaviors were tested at 1 day after the end of the 21 days of stress exposure. Blood samples were collected for serum corticosterone measurement. Brain sections containing hippocampus were stained with hematoxylin and eosin (H&E) as well as by immunohistochemistry for heat shock protein 70 (hsp70) and nitric oxide synthase type 2 (nos2) analyses. The experimental results demonstrated that repetitive dosing of noradrenalin, phentolamine, and propranolol during chronic stress might region-dependently attenuate stress-induced microstructural and biochemical changes in the hippocampus, although propranolol intensified stress-induced behavioral changes.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.aanat.2011.06.001 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Neurotrophin-3 as a mediator in the link between PM exposure and psychiatric disorders: A Mendelian randomization study.
Ecotoxicol Environ Saf
January 2025
School of Public Health, Cheeloo College of Medicine, Shandong University, Jinan, China; Clinical Epidemiology Unit, Qilu Hospital of Shandong University, Jinan, China; Clinical Research Center of Shandong University, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, China. Electronic address:
Background: The causal relationship between PM (particulate matter with an aerodynamic diameter ≤2.5 μm) and common mental disorders, along with its neuropathological mechanisms, remains unclear.
Methods: We used genome-wide association study datasets from the UK Biobank and Psychiatric Genomics Consortium to systematically investigate the causal relationship between PM and nine common psychiatric disorders using two-sample Mendelian randomization (TSMR) methods.
Effects of 5 G mobile phone network electromagnetic field exposure on testicular endoplasmic reticulum stress and the protective role of coenzyme Q10.
Arch Med Res
January 2025
Department of Histology and Embryology, Faculty of Medicine, Recep Tayyip Erdogan University, Rize, Turkey. Electronic address:
Aim: Nowadays, the electromagnetic field (EMF) has become an issue of electromagnetic pollution. This study aimed to determine the effect of 5 G Fr1 frequency band EMF waves on endoplasmic reticulum (ER) stress in testicular tissue and to demonstrate the efficacy of coenzyme Q10 (CoQ10) in suppressing the potential situation.
Materials And Methods: Three groups of eight male Sprague-Dawley rats were established.
Long-term exposure to Emamectin benzoate impairs reproductive health in adult zebrafish and alters neurodevelopment in their offspring.
J Hazard Mater
December 2024
Key Laboratory of Pesticide Environmental Assessment and Pollution Control, Nanjing Institute of Environmental Sciences, Ministry of Ecology and Environment, Nanjing 210042, China. Electronic address:
Emamectin benzoate (EMB) is a widely used insecticide that can accumulate in aquatic environments under specific conditions of high application intensity or improper management, posing potential risks to aquatic organisms and human health. This study aimed to evaluate the reproductive toxicity of long-term EMB exposure in zebrafish (Danio rerio) and neurodevelopmental toxicity in their offspring. Zebrafish embryos were exposed to various concentrations of EMB (0, 0.
View Article and Find Full Text PDFCharacterization of metalaxyl-induced notochord toxicity based on biochemical and transcriptomics in zebrafish (Danio rerio) model.
J Hazard Mater
December 2024
Shanghai Key Laboratory of Anesthesiology and Brain Functional Modulation, Clinical Research Center for Anesthesiology and Perioperative Medicine,Translational Research Institute of Brain and Brain-Like Intelligence, Department of Pediatrics, Shanghai Fourth People's Hospital, School of Medicine, Tongji University, Shanghai 200434, China; Institute of Medical Genetics, Department of Big Data in Health Science School of Public Health and General Practice Medicine, Tongji University School of Medicine, Tongji University, Shanghai 200331, China. Electronic address:
Metalaxyl is an acylanilide systemic fungicide that is widely applied and can readily enter ecosystems through leaching and soil runoff. This research utilized zebrafish as a model organism to thoroughly investigate the detrimental impacts of environmentally relevant levels of metalaxyl on the development of the notochord in zebrafish embryos and to elucidate the underlying molecular mechanisms through transcriptomics, pharmacological intervention and molecular biological detection. The preliminary results demonstrated that metalaxyl induced significant modifications in the developmental parameters of zebrafish embryos.
View Article and Find Full Text PDFBuckwheat responds to co-exposure to PLA microplastics and Pb by regulating the synthesis of unsaturated fatty acids and jasmonates.
J Hazard Mater
December 2024
College of Resources, Sichuan Agricultural University, Chengdu 611130, China. Electronic address:
Polylactic acid (PLA) microplastics (MPs) and lead (Pb) co-contamination, an emerging co-contamination, may profoundly impact plant growth. We aimed to evaluate the effects of PLA-MPs and Pb on buckwheat growth and physiology and to elucidate the underlying molecular mechanisms through an integrated transcriptomic and metabolomic approach. PLA-MPs alone reduced buckwheat biomass by 26.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!