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Gut microbiota mediated T cells regulation and autoimmune diseases.
Front Microbiol
December 2024
Laboratory of Anti-allergic Functional Molecules, College of Life Sciences and Medicine, Zhejiang Sci-Tech University, Hangzhou, China.
Gut microbiota regulates the immune system, the development and progression of autoimmune diseases (AIDs) and overall health. Recent studies have played a crucial part in understanding the specific role of different gut bacterial strains and their metabolites in different AIDs. Microbial signatures in AIDs are revealed by advanced sequencing and metabolomics studies.
View Article and Find Full Text PDFNanoparticle and microparticle-based systems for enhanced oral insulin delivery: A systematic review and meta-analysis.
J Nanobiotechnology
December 2024
Departamento de Farmacia, Facultad de Química, Universidad Nacional Autónoma de México, 04510, Ciudad de Mexico, Mexico.
Diabetes mellitus (DM) prevalence is rising worldwide. Current therapies comprising subcutaneous insulin injections can cause adverse effects such as lipodystrophy, local reactions like redness and swelling, fluid retention, and allergic reactions. Nanoparticle carriers for oral insulin are groundbreaking compared to existing methods because they are non-invasive treatments, showing operational convenience, controlled release profile, and ability to simulate the physiological delivery route into the bloodstream.
View Article and Find Full Text PDFextract attenuates combined allergic rhinitis and asthma syndrome by the modulation of epithelial cell dysfunction and oxidative stress.
Acta Biochim Biophys Sin (Shanghai)
December 2024
Department of Anatomy, Jeonbuk National University Medical School, Jeonju 54896, Republic of Korea.
( . ) has long been a part of the human diet and medicine. Although .
View Article and Find Full Text PDFCoriander: A holistic outlook on its chemistry and pharmacology.
Food Chem
December 2024
Department of Chemistry, North Eastern Regional Institute of Science and Technology, Nirjuli, Itanagar, Arunachal Pradesh 791109, India. Electronic address:
Coriander (Coriandrum sativum L.) is a nutraceutically renowned annual herb from Apiaceae family and used in cuisines in different countries in different ways to enhance the tastes, flavour and nutritional values of foods. Fruit (seed) has several medicinally valuable chemical components viz.
View Article and Find Full Text PDFDiscontinuation of biologic and target-specific therapy in patients with rheumatoid arthritis: a retrospective cohort study.
Rheumatol Int
December 2024
Clinic of Rheumatology, UMHAT "Kaspela", Medical University of Plovaffiliation, 64 Sofia str, Plovaffiliation, 4000, Bulgaria.
Background: Rheumatoid arthritis is a progressive disease that requires continuous treatment. Despite the excellent results, treatment with biologics and target-specific disease-modifying anti-rheumatic drugs often has to be interrupted due to insufficient therapeutic effectiveness, toxicity, or side effects.
Purpose: The purpose of this study is to identify the reasons and factors influencing treatment discontinuation with biologic and target-specific drugs among the Bulgarian patients with rheumatoid arthritis.
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