AI Article Synopsis
- The synthesis process involves two stages using a continuous flow method, specifically microwave-assisted organic synthesis (MACOS).
- Initially, a keto alkyl halide undergoes a displacement reaction to produce a reactive alkyl azide.
- This alkyl azide is then reacted with trifluoroacetic acid (TFA) in the flow system to create a lactam without needing to isolate the azide first.
Article Abstract
A two-stage synthesis of lactams in flow is described. Thus, a keto alkyl halide is displaced in a microwave-assisted, continuous flow organic synthesis format (MACOS) to generate a reactive alkyl azide. Without isolation, a flowed solution containing this azide is then combined with TFA to afford a lactam.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3382118 | PMC |
| http://dx.doi.org/10.1002/chem.201100768 | DOI Listing |
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