AI Article Synopsis
- Systemic sclerosis affects the esophagus in 90% of cases, leading to symptoms like dysphagia and gastroesophageal reflux, along with other gastrointestinal issues in various organs.
- Gastric symptoms arise from gastroparesis, resulting in post-meal fullness and nausea, while intestinal issues lead to problems like abdominal bloating and poor nutrient absorption.
- Diagnosis involves techniques such as imaging and endoscopy, and treatment typically includes prokinetic medications, proton pump inhibitors, and antibiotics to manage symptoms and complications.
Article Abstract
In systemic sclerosis esophagus is affected in 90% followed by anal and rectal involvement (50-70%), stomach (40-70%), colon (10-50%) and small bowel (40%). The main clinical findings are esophagic: dysphagia and sign of gastroesophageal reflux and its complications. Gastric symptomatology is a consequence of gastroparesis (postprandial fullness, nausea). Intestinal affection produces hypomotility (abdominal distention, deficient intestinal absorption, bacterial overgrowth). In colon there are diverticula, intestinal constipation, and fecal incontinence. For the diagnosis of GIT involvement the following are useful: studies of digestive tract with contrast media, endoscopy of upper GIT; gastric emptying; pH metry; esophageal and rectal manometry, as well as test to investigate deficient intestinal absorption syndrome. The prokinetic are a cornerstone for the treatment of hypomotility of GIT, along with pump proton inhibitors for the esophageal alteration and antibiotics for bacterial overgrowth.
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| http://dx.doi.org/10.1016/S1699-258X(06)73104-7 | DOI Listing |
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