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Variation of the Risk Associated With Potentially Modifiable Risk Factors for Dementia Between Ethnic Groups Within One Country. A Retrospective Cohort Study Using Routinely Collected Health Data in Aotearoa New Zealand.
Int J Geriatr Psychiatry
January 2025
Division of Psychiatry, University College London, London, UK.
Introduction: While risk factor prevalence of individual risk factors for dementia varies between ethnic groups in New Zealand (NZ), it is not known whether the effect of these risks is the same in each group.
Methods: This retrospective cohort study identified incident cases of dementia. Cox regression models calculated the hazard ratio for dementia for each of the risk factors, after adjustment for age and sex.
A foundation model of transcription across human cell types.
Nature
January 2025
Program of Mathematical Genomics, Department of Systems Biology, Columbia University, New York, NY, USA.
Transcriptional regulation, which involves a complex interplay between regulatory sequences and proteins, directs all biological processes. Computational models of transcription lack generalizability to accurately extrapolate to unseen cell types and conditions. Here we introduce GET (general expression transformer), an interpretable foundation model designed to uncover regulatory grammars across 213 human fetal and adult cell types.
View Article and Find Full Text PDFBlood metal levels predict digestive tract cancer risk using machine learning in a U.S. cohort.
Sci Rep
January 2025
School of Environmental and Biological Engineering, Nanjing University of Science and Technology, Nanjing, 210094, China.
Background: Environmental metal exposure has been implicated in the development of digestive tract cancers, although the specific associations remain poorly defined. This study aimed to investigate the relationship between blood metal levels and the risk of digestive tract cancers among U.S.
View Article and Find Full Text PDFThe persuasive role of generic-you in online interactions.
Sci Rep
January 2025
Department of Psychology, Bryn Mawr College, Bryn Mawr, PA, USA.
Persuasion plays a crucial role in human communication. Yet, convincing someone to change their mind is often challenging. Here, we demonstrate that a subtle linguistic device, generic-you (i.
View Article and Find Full Text PDFThe hidden cost of digital learning: a cross-sectional study assessing the prevalence of computer vision syndrome (CVS) among medical students in Jordan.
BMJ Open
January 2025
Department of Special Surgery, The Hashemite University Faculty of Medicine, Zarqa, Jordan.
Objective: Increased screen time has resulted in widespread computer vision syndrome (CVS) in the digital era. Medical students, who rely heavily on digital screens, are particularly at risk. Our study aims to evaluate the prevalence of CVS among Jordanian medical students, which is a gap in existing knowledge.
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