AI Article Synopsis
- Many hearing disorders result from damage to sensory hair cells, leading to severe and permanent deafness.
- Research indicates that the apoptosis pathway plays a key role in the rapid worsening of hair cell damage after exposure to loud noises.
- Recent advancements in understanding the molecular mechanisms behind sensory cell survival and regeneration suggest that targeted therapies could help preserve hearing and potentially prevent noise-induced deafness.
Article Abstract
Many hearing disorders are associated with the damage or loss of sensory hair cells (HC) which can produce a profound and irreversible deafness. Apoptosis pathway is reported to play an important role leading to rapid expansion of the HC lesion after exposure to intense noise. Furthermore, progress made over the last year in understanding molecular mechanisms involved in the proliferative and regenerative capacity of sensory cells in the mammalian inner ear has raised the possibility that targeted therapies might prevent the loss of these cells and preserve the patient's hearing. A first step towards the successful therapeutic exploitation is a better understanding of the different pathways that control survival and proliferation of sensory cells. In this review, we provide an overview of recent findings concerning the possibility to prevent apoptosis in auditory cells. We also show the current knowledge on the molecular mechanisms involved in the potential regenerative behavior of these cells and the progress of gene therapy to prevent deafness noise-induced.
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| http://dx.doi.org/10.1002/jcp.22617 | DOI Listing |
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