AI Article Synopsis
- A 20-month-old toddler with a medulla oblongata abscess was successfully treated using a novel surgical approach, making it a unique case in medical literature.
- Preoperative imaging, specifically diffusion tensor imaging (DTI) tractography, guided the surgical team to choose a midline suboccipital approach, allowing effective access to the abscess.
- The successful surgery and the child's full recovery underscore the importance of advanced neuroimaging techniques in enhancing surgical planning and ensuring patient safety.
Article Abstract
Background And Importance: We report a unique case of a toddler (the only one reported) successfully operated on for a medulla oblongata abscess and comment on the influence of neuroimaging modalities in the preoperative planning of the surgical approach.
Clinical Presentation: We report a case of a 20-month-old child with a solitary medulla oblongata abscess. The abscess appeared to be in close proximity to the anterior medulla oblongata, but preoperative planning based on diffusion tensor imaging (DTI) tractography motivated us to try to remove this lesion through a midline suboccipital approach. The ventral medulla oblongata abscess was surgically removed via a telovelar approach. At the anterior wall of the 4th ventricle, a fenestration was made with pus release and evacuation of the cavity. The child was discharged 1 week later with an uneventful and full recovery.
Conclusion: Modern imaging modalities of the nervous system can be very helpful in preoperative planning. Functional visualization of the nervous system provided by modern imaging techniques, such as the DTI tractography, can alter the classic topographic concept of surgical approach. In the case presented, approaching an anterior medulla oblongata abscess based on DTI tractography data, through a suboccipital midline transventricular approach, proved to be an effective and safe technique.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1227/NEU.0b013e318218cf37 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Brainstem BDNF neurons are downstream of GFRAL/GLP1R signalling.
Nat Commun
December 2024
Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK.
Growth differentiation factor 15, GDF15, and glucagon-like peptide-1 (GLP-1) analogues act through brainstem neurons that co-localise their receptors, GDNF-family receptor α-like (GFRAL) and GLP1R, to reduce food intake and body weight. However, their use as clinical treatments is partially hampered since both can also induce sickness-like behaviours, including aversion, that are mediated through a well-characterised pathway via the exterolateral parabrachial nucleus. Here, in mice, we describe a separate pathway downstream of GFRAL/GLP1R neurons that involves a distinct population of brain-derived neurotrophic factor (BDNF) cells in the medial nucleus of the tractus solitarius.
View Article and Find Full Text PDF3D-printed suction clamps for tensile testing of brain tissue.
J Mech Behav Biomed Mater
December 2024
Department of Oral Rehabilitation, University of Otago, 310 Great King Street North, Dunedin, New Zealand.
The conventional mounting of ultra-soft biological tissues often involves gluing it between two plates or manually tightening grips. Both methods demand delicate handling skills and are time-consuming. This study outlines the design and practical application of 3D-printed suction clamps for uniaxial tension tests on brain samples.
View Article and Find Full Text PDFAged mice show a reduction in 5-HT neurons and decreased cellular activation in the dentate gyrus when exposed to acute running.
Brain Struct Funct
December 2024
Laboratory of Molecular and Functional Neurobiology, Department of Pharmacology, Institute of Biomedical Sciences, University of São Paulo, Av. Prof. Lineu Prestes, 1524, São Paulo, SP, 05508-000, Brazil.
Serotonin (5-HT) is an important neurotransmitter for cognition and neurogenesis in the dentate gyrus (DG), which occurs via movement stimulation such as physical activity. Brain 5-HT function changes secondary to aging require further investigation. We evaluated whether aged animals would present changes in the number of 5-HT neurons in regions such as the dorsal (DRN) and median (MRN) raphe nuclei and possible changes in the rate of cellular activation in the DG in response to acute running, as a reduction in 5-HT neurons could contribute to a decline in neuronal activation in the DG in response to physical activity in aged mice.
View Article and Find Full Text PDFThe Inferior Cerebellar Peduncle Sign: A Novel Imaging Marker for Differentiating Multiple System Atrophy Cerebellar Type from Spinocerebellar Ataxia.
AJNR Am J Neuroradiol
December 2024
From the Department of Radiology and Center for Imaging Science (C.Y.L., Y.S., B.S., M.S., S.T.K., E.Y.K.), Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea; Department of Digital Health (S.H.), Samsung Advanced Institute of Health Sciences and Technology (SAIHST), Sungkyunkwan University, Seoul, Republic of Korea; Medical AI Research Center, Research Institute for Future Medicine (S.H.), Samsung Medical Center, Seoul, Republic of Korea; Department of Neurology (J.Y.), Neuroscience Center (J.Y.), Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.
Background And Purpose: The hot cross bun (HCB) sign is a hallmark feature of multiple system atrophy with predominant cerebellar ataxia (MSA-C), typically observed in advanced stages of the disease; however, it can also present in other conditions such as spinocerebellar ataxia (SCA), making the differentiation challenging. The middle cerebellar peduncle (MCP) sign may be observed in various medical conditions and in healthy individuals. We hypothesized that the inferior cerebellar peduncle (ICP), known to be affected in MSA-C, may exhibit hyperintensity on fluid-attenuated inversion recovery (FLAIR) imaging, potentially aiding in differentiating MSA-C from SCA.
View Article and Find Full Text PDFPosterior dislocation of the atlantoaxial joint with compression of the medulla oblongata and cervical spinal cord: A case report.
Asian J Surg
December 2024
Orthopedics Department, Gansu Provincial Hospital, No.204, Donggang WestRoad, Lanzhou, 730000, Gansu Province, China. Electronic address:
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!