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Light-chain amyloidosis with concomitant symptomatic myeloma (CRAB-SLiM features): clinical characteristics, cytogenetic abnormalities, and outcomes.
BMC Cancer
November 2024
Department of Hematology, Zhongshan Hospital, Fudan University, 180 Fenglin Road, Shanghai, 200032, PR China.
Background: Patients with light-chain (AL) amyloidosis and concomitant multiple myeloma (MM) are known to have a worse prognosis, while the prognostic implication of cytogenetic abnormalities (CA) and optimal treatment schemes are not well-established. By comparing patients with MM or AL amyloidosis (AL) alone, this study aimed to evaluate the clinical characteristics, CA, and outcomes of patients with AL amyloidosis and concomitant symptomatic MM (MM-AL) and sought to provide evidence for their management.
Methods: In total, 915 consecutive patients with newly diagnosed AL amyloidosis or MM were retrospectively analyzed.
Evaluation of ploidy and the DNA index by flow cytometry in central nervous system tumors: a review.
Mol Biol Rep
November 2024
Human Genetics Institute "Dr. Enrique Corona-Rivera", Molecular Biology and Genomics Department, University Center of Health Sciences/Ph.D. Human Genetics Program, University of Guadalajara, Sierra Mojada #950, Independencia Oriente, Guadalajara, Jalisco, C.P. 44340, México.
Research on central nervous system tumors (CNSTs) has a significant impact on the diagnosis and prognosis of patients. Currently, CNSTs are classified according to the schema proposed by the World Health Organization (WHO), which considers clinical, histopathological, and molecular characteristics, highlighting the importance of tumor biology for accurate diagnosis and optimal treatment approaches. Despite these advances, assessing DNA ploidy-a marker of tumor aggressiveness-remains complex in CNSTs.
View Article and Find Full Text PDFLow-level mosaic trisomy 21 due to mosaic unbalanced Robertsonian translocation of 46,XX,+21,der(21;21) (q10;q10)/46,XX at amniocentesis in a pregnancy associated with a favorable fetal outcome, cytogenetic discrepancy between cultured amniocytes and uncultured amniocytes, cytogenetic discrepancy among various tissues and perinatal progressive decrease of the trisomy 21 cell line.
Taiwan J Obstet Gynecol
November 2024
Department of Medical Research, MacKay Memorial Hospital, Taipei, Taiwan.
Article Synopsis
- Prenatal diagnosis of mosaic trisomy 21 was successfully performed on a 41-year-old woman during an amniocentesis, revealing a mix of normal and abnormal cells in the fetus due to a Robertsonian translocation.
- Despite initial concerns, subsequent tests showed significant normalization in fetal cells, leading to a reassuring outcome.
- At 38 weeks, the mother delivered a healthy baby with normal development, confirming that even low-level chromosomal abnormalities can result in positive pregnancy outcomes.
Complete cytogenetic discrepancy between cultured amniocytes and uncultured amniocytes is common in mosaic trisomy 20 at amniocentesis with positive conventional cytogenetic analysis and negative chromosomal microarray analysis.
Taiwan J Obstet Gynecol
September 2024
Department of Obstetrics and Gynecology, MacKay Memorial Hospital, Taipei, Taiwan; Department of Medical Research, MacKay Memorial Hospital, Taipei, Taiwan; School of Chinese Medicine, College of Chinese Medicine, China Medical University, Taichung, Taiwan; Institute of Clinical and Community Health Nursing, National Yang Ming Chiao Tung University, Taipei, Taiwan; Department of Obstetrics and Gynecology, School of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan; Department of Medical Laboratory Science and Biotechnology, College of Medical and Health Science, Asia University, Taichung, Taiwan. Electronic address:
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