AI Article Synopsis
- SCLC is a fast-growing and aggressive lung cancer that spreads quickly and responds well to chemotherapy, but often relapses, leading to poor survival rates.
- Researchers are exploring new molecular targets through ongoing studies to find better treatment options for patients with SCLC.
- The review focuses on these potential targets and new therapies being tested in clinical trials to enhance patient outcomes.
Article Abstract
Small cell lung cancer (SCLC) is an aggressive form of lung cancer that is characterized by a rapid doubling time, early onset of dissemination and high sensitivity to chemotherapy. Despite the potential for cure in patients with limited disease with concurrent chemoradiation and an initial good response to chemotherapy in extensive disease, there is a high chance of disease relapse with an overall poor median survival for both stages. With increasing translational research and a better understanding of the molecular basis of cancer, a number of molecular targets have been identified in various preclinical studies. This review summarizes potentially viable targets and new agents that have been developed and employed in recent, ongoing and future clinical trials to attempt to improve clinical outcomes in this disease.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3126006 | PMC |
| http://dx.doi.org/10.1177/1758834009356014 | DOI Listing |
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