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Single-Neuron Labeling in Using Multicolor FLP-Out.
Cold Spring Harb Protoc
September 2024
Department of Molecular Genetics and Cell Biology, The University of Chicago, Chicago, Illinois 60637, USA
Neurons exhibit some of the most striking examples of morphological diversity of any cell type. Thus, when studying neurons, the morphology of each neuron must be considered individually. However, neurons densely populate the central nervous system (CNS), making it difficult to ascertain fine morphological features due to a lack of spatial resolution.
View Article and Find Full Text PDFInflammatory injury induces pain sensitization that is expressed beyond the site of injury in male (and not in female) mice.
Behav Brain Res
October 2024
Department of Psychology, University of Toronto, Canada; Cell and Systems Biology, University of Toronto, Canada. Electronic address:
Pain is a crucial protective mechanism for the body. It alerts us to potential tissue damage or injury and promotes the avoidance of harmful stimuli. Injury-induced inflammation and tissue damage lead to pain sensitization, which amplifies responses to subsequent noxious stimuli even after an initial primary injury has recovered.
View Article and Find Full Text PDFPyruvate dehydrogenase complex deficiency masked by septic shock-induced lactic acidosis: a case report.
J Int Med Res
May 2024
Emergency Department, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, China.
Pyruvate dehydrogenase complex (PDHC) deficiency is a common genetic disorder leading to lactic acidosis, which can also result from several nongenetic conditions, such as septic shock. The present study reports a case of PDHC deficiency masked by septic shock-induced lactic acidosis. This case involved a 16-year-old adolescent with poor exercise tolerance compared with his peers, and no underlying diseases.
View Article and Find Full Text PDFCytokine storm complicated by cardiogenic shock induced by anti-HER2 therapies.
J Immunother Cancer
June 2023
Department of Medicine, Immunology and allergy division, Lausanne University Hospital CHUV, Lausanne, Switzerland
Cytokine storm induced by anti-human epidermal growth factor receptor-2 (HER2) therapies has not been reported. We report a patient with breast cancer treated with trastuzumab/pertuzumab who developed severe biventricular dysfunction and cardiogenic shock (CS) 6 months after starting double anti-HER2 therapy. The CS was accompanied by severe systemic inflammation, and cardiac MRI (cMRI) showed structural changes typical of myocardial inflammation.
View Article and Find Full Text PDFApplication of single cell multiomics points to changes in chromatin accessibility near calcitonin receptor like receptor and a possible role for adrenomedullin in the post-shock lung.
Front Med (Lausanne)
April 2023
Lifespan-Rhode Island Hospital, Providence, RI, United States.
Introduction: Acute lung injury (ALI)/acute respiratory distress syndrome (ARDS) is a commonly occurring sequelae of traumatic injury resulting from indirect insults like hypovolemic shock and/or extrapulmonary sepsis. The high lethality rate associated with these pathologies outlines the importance of clarifying the "priming" effects seen in the post-shock lung microenvironment, which are understood to bring about a dysregulated or overt immune response when triggered by a secondary systemic infectious/septic challenge culminating in ALI. In this pilot project, we test the hypothesis that application of a single cell multiomics approach can elucidate novel phenotype specific pathways potentially contributing to shock-induced ALI/ARDS.
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