This review focuses on arborviral infections associated with California serocomplex (Bunyaviridae, Orthobunyavirus). Results of relevant eco-epidemiological and clinical studies in Russia are presented suggesting the ubiquitious nature of diseases caused by viruses of the California encephalitis serocomplex (Inko, Tahyna, Snowshoe Hare). The etiologic structure of these diseases in taiga and mixed woods of the European part and Western Siberia is dominated by the Inco virus and in southern regions by Tahina. The diseases have a well apparent seasonal pattern (July-August) in agreement with the peak summer activity of the pathogens. Two clinical forms of pathology are distinguished, influenza-like and generalized, the latter affecting lungs, kidneys, liver, and CNS. The Inco virus plays a key role in pathogenesis of the generalized form affecting CNS.
Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
A single-cell compendium of human cerebrospinal fluid identifies disease-associated immune cell populations.
J Clin Invest
January 2025
Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, Missouri, USA.
Single-cell transcriptomics applied to cerebrospinal fluid (CSF) for elucidating the pathophysiology of neurologic diseases has produced only a preliminary characterization of CSF immune cells. CSF derives from and borders central nervous system (CNS) tissue, allowing for comprehensive accounting of cell types along with their relative abundance and immunologic profiles relevant to CNS diseases. Using integration techniques applied to publicly available datasets in combination with our own studies, we generated a compendium with 139 subjects encompassing 135 CSF and 58 blood samples.
View Article and Find Full Text PDFQuantitative evaluation of electrographic response to electroconvulsive therapy in super-refractory status epilepticus.
Front Neurol
December 2024
Department of Neurology, University of California, San Francisco, San Francisco, CA, United States.
Objective: Electroconvulsive therapy (ECT) has been occasionally applied as a treatment for super-refractory status epilepticus (SRSE). However, the effects of ECT on electrographic activity and related clinical outcomes are largely unknown. Here, we use quantitative approaches on electroencephalography (EEG) data to evaluate the neurophysiological influences of ECT and how they may relate to patient survival.
View Article and Find Full Text PDFCentral Nervous System Vasculitis in an Immunocompetent Child: Case Report.
J Child Neurol
December 2024
Department of Neurology, University of California, Davis, Davis, CA, USA.
granulomatous amebic encephalitis is a rare disease that is associated with a high rate of mortality. Delays in diagnosis and treatment are common because of limited information on the organism in addition to its nonspecific clinical presentation. Prior reports have demonstrated that the encephalitis presents as multifocal lesions throughout the central nervous system with enhancement and edema.
View Article and Find Full Text PDFA Serological Assay for the Detection of Antibodies Generated Against California Serogroup Virus Infection.
Methods Mol Biol
December 2024
Public Health Agency of Canada (PHAC), Winnipeg, MB, Canada.
The California serogroup (CSG) viruses are orthobunyaviruses endemic in North America and responsible for the second most common cause of mosquito-borne viral encephalitis in the United States. As the CSG viruses have been neglected and are poorly studied, there are no commercial diagnostic serological assays or reagents available for detection. Therefore, diagnostic laboratories have had to rely on the development of their own in-house serological assays.
View Article and Find Full Text PDFAnalysis of Powassan Virus Genome Sequences from Human Cases Reveals Substantial Genetic Diversity with Implications for Molecular Assay Development.
Viruses
October 2024
Department of Pathology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.
Powassan virus (POWV) is an emerging tick-borne virus that causes severe meningoencephalitis in the United States, Canada, and Russia. Serology is generally the preferred diagnostic modality, but PCR on cerebrospinal fluid, blood, or urine has an important role, particularly in immunocompromised patients who are unable to mount a serologic response. Although the perceived poor sensitivity of PCR in the general population may be due to the biology of infection and health-seeking behavior (with short viremic periods that end before hospital presentation), limitations in assay design may also contribute.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!