AI Article Synopsis
- A new phenanthrenedione named pterolinus K and a new chalcone called pterolinus L were discovered from the heartwood extract of Pterocarpus santalinus.
- Both compounds were analyzed using spectroscopic methods to determine their structures.
- Pterolinus K exhibited strong inhibitory effects on human neutrophil elastase and superoxide anion generation, along with selective cytotoxicity against HepG2 cancer cells, while pterolinus L showed moderate cytotoxicity against KB cells.
Article Abstract
One new phenanthrenedione, pterolinus K (1), and one new chalcone, pterolinus L (2) were isolated from the heartwood extract of Pterocarpus santalinus. The structures were elucidated by spectroscopic methods. Both 1 and 2 showed inhibitory effect on elastase release by human neutrophils in response to fMLP with an IC(50) value of 4.24 and 0.95 μM, and compound 1 also inhibited superoxide anion generation with IC(50) value of 0.99 μM. In addition, compound 1 showed selective cytotoxicity against HepG2 with IC(50) value of 10.86 μM, while compound 2 showed a moderate cytotoxicity against KB with IC(50) values of 17.18 μM.
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| http://dx.doi.org/10.1016/j.bmcl.2011.06.036 | DOI Listing |
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