AI Article Synopsis
- Amyloid imaging abnormalities (ARIA) have been observed in clinical trials aimed at reducing amyloid-β in Alzheimer's disease, drawing attention from the FDA.
- A working group from the Alzheimer’s Association reviewed trial data, animal models, and literature to better understand ARIA, which encompasses two types: ARIA-E (edema) and ARIA-H (hemosiderin deposits).
- Although the cause of ARIA is still unclear, it’s suggested that vascular amyloid may play a significant role, leading to increased permeability in blood vessels, prompting the need for better detection and monitoring methods in ongoing trials.
Article Abstract
Amyloid imaging related abnormalities (ARIA) have now been reported in clinical trials with multiple therapeutic avenues to lower amyloid-β burden in Alzheimer's disease (AD). In response to concerns raised by the Food and Drug Administration, the Alzheimer's Association Research Roundtable convened a working group to review the publicly available trial data, attempts at developing animal models, and the literature on the natural history and pathology of related conditions. The spectrum of ARIA includes signal hyperintensities on fluid attenuation inversion recoverysequences thought to represent "vasogenic edema" and/or sulcal effusion (ARIA-E), as well as signal hypointensities on GRE/T2* thought to represent hemosiderin deposits (ARIA-H), including microhemorrhage and superficial siderosis. The etiology of ARIA remains unclear but the prevailing data support vascular amyloid as a common pathophysiological mechanism leading to increased vascular permeability. The workgroup proposes recommendations for the detection and monitoring of ARIA in ongoing AD clinical trials, as well as directions for future research.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3693547 | PMC |
| http://dx.doi.org/10.1016/j.jalz.2011.05.2351 | DOI Listing |
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