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A Randomized clinical trial comparing the efficacy of ultrasound-guided erector spinae block and paravertebral block in preventing postherpetic neuralgia in patients with zoster-associated pain.
J Anaesthesiol Clin Pharmacol
March 2024
Department of Anaesthesiology, Venereology and Leprosy, JSS Academy of Higher Education and Research, Mysuru, Karnataka, India.
Article Synopsis
- The study investigates the effectiveness of two pain management techniques, paravertebral block (PVB) and erector-spinae block (ESPB), for treating patients with acute herpes zoster (AHZ) to prevent postherpetic neuralgia (PHN).
- A total of 60 patients were randomly assigned to receive either standard treatment alone, standard treatment with PVB, or standard treatment with ESPB, with pain relief evaluated over a 60-day period.
- Results showed significantly lower rates of PHN in the PVB and ESPB groups (40% and 45%, respectively) compared to the control group (80%), indicating both blocks are effective in reducing pain and preventing PHN progression.
COVID-19 hospitalisations in a tertiary health service during the Omicron subvariant wave.
Aust N Z J Public Health
August 2024
Monash University School of Clinical Sciences at Monash Health, Monash Medical Centre, Clayton, VIC 3168, Australia; South East Public Health Unit, Monash Health, Clayton, Vic 3168, Australia; Epidemiology and Infection Prevention, Monash Health, Clayton, Vic 3168, Australia. Electronic address:
Objectives: COVID-19 Omicron subvariants typically cause milder disease than previous strains, yet many patients were still admitted to hospital for acute care. We audited reasons for and details of admissions to identify opportunities to reduce hospitalisations.
Methods: We reviewed all admitted patients who tested positive for SARS-CoV-2 from 1 December 2022 to 30 January 2023.
Functional diversification of innate and inflammatory immune responses mediated by antibody fragment crystallizable activities against SARS-CoV-2.
iScience
May 2024
Department of Infectious Diseases, Istituto Superiore di Sanità, 00161 Rome, Italy.
Monoclonal antibodies (mAb) targeting the SARS-CoV-2 Spike (S) glycoprotein have been exploited for the treatment of severe COVID-19. In this study, we evaluated the immune-regulatory features of two neutralizing anti-S mAbs (nAbs), named J08 and F05, with wild-type (WT) conformation or silenced Fc functions. In the presence of D614G SARS-CoV-2, WT nAbs enhance intracellular viral uptake in immune cells and amplify antiviral type I Interferon and inflammatory cytokine and chemokine production without viral replication, promoting the differentiation of CD16 inflammatory monocytes and innate/adaptive PD-L1 and PD-L1CD80 plasmacytoid Dendritic Cells.
View Article and Find Full Text PDFAdverse outcomes in patients hospitalized with pneumonia at age 60 or more: A prospective multi-centric hospital-based study in India.
PLoS One
May 2024
Centre for Community Medicine, All India Institute of Medical Sciences, New Delhi, India.
Background: Limited data exists regarding risk factors for adverse outcomes in older adults hospitalized with Community-Acquired Pneumonia (CAP) in low- and middle-income countries such as India. This multisite study aimed to assess outcomes and associated risk factors among adults aged ≥60 years hospitalized with pneumonia.
Methods: Between December 2018 and March 2020, we enrolled ≥60-year-old adults admitted within 48 hours for CAP treatment across 16 public and private facilities in four sites.
Relative band power in assessing temporary neurological dysfunction post- type A aortic dissection surgery: a prospective study.
Sci Rep
April 2024
Department of Cardio-Thoracic Surgery, Nanjing Drum Tower Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China.
Temporary neurological dysfunction (TND), a common complication following surgical repair of Type A Aortic Dissection (TAAD), is closely associated with increased mortality and long-term cognitive impairment. Currently, effective treatment options for TND remain elusive. Therefore, we sought to investigate the potential of postoperative relative band power (RBP) in predicting the occurrence of postoperative TND, with the aim of identifying high-risk patients prior to the onset of TND.
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