AI Article Synopsis
- Human urine is rich in proteins and peptides, referred to as the urinary proteome, which can help in studying urinary tract diseases.
- Bladder cancer, the most common urological cancer, has higher rates in areas affected by Blackfoot disease in southern Taiwan, highlighting the need for better diagnostic tools.
- The study aimed to identify urinary protein biomarkers for bladder cancer, and ADAM28 was found to be significantly different in bladder cancer patients compared to healthy individuals, suggesting its potential as a biomarker.
Article Abstract
Human urine contains a large number of proteins and peptides (the urinary proteome). Global analysis of the human urinary proteome is important for understanding urinary tract diseases. Bladder cancer is the most common urological cancer with higher incidence rates in endemic areas of Blackfoot disease (BFD) in southern Taiwan. The aim of this study was to use the proteomic approach to establish urinary protein biomarkers of bladder cancer. ADAM28, identified by proteomic approaches and confirmed by Western blotting, showed significant differences compared with normal individuals, so it may be a biomarker of bladder cancer.
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