The main purpose of the study was to evaluate the effects of low-esterified pectin on lead-induced thyroid injury in rats. Animals were fed 100mg/kg of lead acetate through gavage for 3 weeks. After that, solution containing 50mg/kg of low-esterified pectin was administered through gavage for 2 weeks. At the end of experiment, the endpoints related to circulating thyroid hormone (serum thyroxine and triiodothyronine), thyroid gland histomorphology (thyroid follicle cross sectional area, epithelial height, follicle roundness or aspect ratio, and colloid/epithelial ratio), and thyroid gland weight were assessed. Administration of lead resulted in reduced blood hormone levels, decreased thyroid gland weight, and impaired alterations in histomorphology. At the end of experiment, thyroid gland weight and blood hormone level were increased because of additional administration of low-esterified pectin. Also, signs of improved thyroid histomorphology were registered. The results obtained indicate the beneficial effects of low-esterified pectin on lead-induced thyroid injury.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.etap.2004.03.001 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Clarification of Bio-Degumming Enzymes Based on a Visual Analysis of the Hemp Roving Structure.
Polymers (Basel)
December 2024
Department of Biotechnology, Institute of Resource Biology and Biotechnology, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan 430074, China.
Hemp fibers, recognized for their breathability, specific strength, and ultraviolet resistance, are widely utilized in textile manufacturing and composite materials. Bio-degumming is a promising alternative technology to traditional chemical degumming that can be used to produce hemp fibers due to its eco-friendly nature. However, its lower efficiency has hindered its widespread adoption.
View Article and Find Full Text PDFMild ultrasound-assisted alkali de-esterification modified pectins: Characterization and structure-activity relationships in immunomodulatory effects.
Ultrason Sonochem
January 2025
College of Biomass Science and Engineering and Healthy Food Evaluation Research Center, Sichuan University, Chengdu 610065, China. Electronic address:
Apple pectin (AP), a well-established dietary fiber, offers significant health benefits, particularly in immunomodulation. However, the structure-activity relationship (SAR) in this context remains poorly understood. This study aimed to elucidate the impact of varying degrees of esterification (DE) on AP's SAR in immunomodulatory activity.
View Article and Find Full Text PDFSynergistic effects of boron and cadmium on the metal enrichment and cell wall immobilization capacity of Cosmosbipinnatus.
Plant Physiol Biochem
November 2024
College of Landscape Architecture, Sichuan Agricultural University, Chengdu 611130, China.
Article Synopsis
- Cadmium (Cd) is a heavy metal that negatively impacts plant growth, while boron (B) is a crucial nutrient that aids in plant development and cell wall synthesis.
- Research on Cosmos bipinnatus reveals that adding exogenous B helps counteract Cd's harmful effects by increasing plant biomass and reducing Cd translocation from roots to shoots.
- The study also shows that B enhances root cell wall properties and mitigates Cd-induced oxidative stress, ultimately improving the plant's tolerance to cadmium pollution.
Potential role of cell wall pectin polysaccharides, water state, and cellular structure on twice "increase-decrease" texture changes during kohlrabi pickling process.
Food Res Int
November 2023
College of Food Science and Technology, Huazhong Agricultural University, Wuhan, Hubei, PR China; Key Laboratory of Environment Correlative Dietology, Ministry of Education, PR China; Hubei Key Laboratory of Fruit & Vegetable Processing & Quality Control (Huazhong Agricultural University), Wuhan, Hubei, PR China. Electronic address:
Pickled kohlrabi is a traditional and favored vegetable product in China. During pickling, the hardness, springiness, and chewiness of kohlrabi all experienced a typical change with twice "increase-decrease" trend. However, little is known about its mechanism.
View Article and Find Full Text PDFPreparation and Characterization of Hydrogel Films and Nanoparticles Based on Low-Esterified Pectin for Anticancer Applications.
Polymers (Basel)
August 2023
Institute of Life Sciences and Biomedicine, Far Eastern Federal University, Vladivostok 690922, Russia.
Prospective adjuvant anticancer therapy development includes the establishing of drug delivery systems based on biocompatible and biodegradable carriers. We have designed films and nanoparticles (NPs) based on low-esterified pectin hydrogel using the ionic gelation method. We investigated morphology, nanomechanical properties, biocompatibility and anticancer activity.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!