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Targeting JAK/STAT3 in glioblastoma cells using an alginate-PNIPAm molecularly imprinted hydrogel for the sustained release of ruxolitinib.
Int J Biol Macromol
January 2025
Department of Analytical Chemistry and Instrumental Analysis, "Iuliu Hațieganu" University of Medicine and Pharmacy, Cluj-Napoca, Romania. Electronic address:
Glioblastoma (GBM) is a notoriously aggressive primary brain tumor characterized by elevated recurrence rates and poor overall survival despite multimodal treatment. Local treatment strategies for GBM are safer and more effective alternatives to systemic chemotherapy, directly tackling residual cancer cells in the resection cavity by circumventing the blood-brain barrier. Molecularly imprinted polymers (MIPs) are promising drug delivery systems due to their high-affinity binding cavities that enable tailored release kinetics.
View Article and Find Full Text PDFEpigenetics in Learning and Memory.
Subcell Biochem
January 2025
Faculty of Medicine and Faculty of Life Sciences, Institute of Biomedical Sciences (ICB), Universidad Andres Bello, Santiago, Chile.
In animals, memory formation and recall are essential for their survival and for adaptations to a complex and often dynamically changing environment. During memory formation, experiences prompt the activation of a selected and sparse population of cells (engram cells) that undergo persistent physical and/or chemical changes allowing long-term memory formation, which can last for decades. Over the past few decades, important progress has been made on elucidating signaling mechanisms by which synaptic transmission leads to the induction of activity-dependent gene regulation programs during the different phases of learning (acquisition, consolidation, and recall).
View Article and Find Full Text PDFPost-Docking Refinement of Peptide or Protein-RNA Complexes Using Thermal Titration Molecular Dynamics (TTMD): A Stability Insight.
J Chem Inf Model
January 2025
Molecular Modeling Section (MMS), Department of Pharmaceutical and Pharmacological Sciences, University of Padova, via Marzolo 5, 35131 Padova, Italy.
RNA-protein interactions drive and regulate fundamental cellular processes like transcription and translation. Despite being still limited, the growing body of structural data significantly contributes to the characterization of these interactions. However, RNA complexes involving proteins or peptides are not always available due to the structural determination challenges that this biopolymer entails.
View Article and Find Full Text PDFYoung people's proposals for tackling everyday challenges in order to improve mental health: a qualitative comparison study based on different socioeconomic neighborhoods.
BMC Public Health
January 2025
Department of Care Science, Faculty of Health and Society, Malmö University, Malmö, Sweden.
Background: Everyday challenges and stress negatively affect young people's mental health. Socioeconomic status (SES) is associated with different stressors and different stress-coping mechanisms. Many interventions target youth mental health, but few consider socioeconomic differences in the planning, implementation, or evaluation.
View Article and Find Full Text PDFOrthologous marker groups reveal broad cell identity conservation across plant single-cell transcriptomes.
Nat Commun
January 2025
Genetics, Bioinformatics, and Computational Biology, Virginia Tech, Blacksburg, VA, USA.
Single-cell RNA sequencing (scRNA-seq) is widely used in plant biology and is a powerful tool for studying cell identity and differentiation. However, the scarcity of known cell-type marker genes and the divergence of marker expression patterns limit the accuracy of cell-type identification and our capacity to investigate cell-type conservation in many species. To tackle this challenge, we devise a novel computational strategy called Orthologous Marker Gene Groups (OMGs), which can identify cell types in both model and non-model plant species and allows for rapid comparison of cell types across many published single-cell maps.
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