Dietary walnut suppressed mammary gland tumorigenesis in the C(3)1 TAg mouse.

Nutr Cancer

Department of Biochemistry and Microbiology, Marshall University School of Medicine, Huntington, West Virginia 25701, USA.

Published: December 2011

Walnuts contain multiple ingredients that, individually, have been shown to slow cancer growth, including omega-3 fatty acids, antioxidants, and phytosterols. In previous research, consumption of walnuts has slowed the growth of implanted breast cancers. We wanted to determine whether regular walnut consumption might reduce the risk for developing cancer. Homozygous male C(3)1 TAg mice were bred with female SV129 mice consuming either the control AIN-76 diet or the walnut-containing diet. At weaning, the female hemizygous pups were randomized to control or walnut-containing diets and followed for tumor development. Compared to a diet without walnuts, consumption of walnuts significantly reduced tumor incidence (fraction of mice with at least one tumor), multiplicity (number of glands with tumor/mouse), and size. Gene expression analyses indicated that consumption of the walnut diet altered expression of multiple genes associated with proliferation and differentiation of mammary epithelial cells. A comparison with another dietary intervention indicated that the omega 3 content alone did not account for the extent of tumor suppression due to the walnut. The results of this study indicate that walnut consumption could contribute to a healthy diet to reduce risk for breast cancer.

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3474134PMC
http://dx.doi.org/10.1080/01635581.2011.589959DOI Listing

Publication Analysis

Top Keywords

c31 tag
8
consumption walnuts
8
walnut consumption
8
reduce risk
8
consumption
5
diet
5
dietary walnut
4
walnut suppressed
4
suppressed mammary
4
mammary gland
4

Similar Publications

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!