AI Article Synopsis
- The study evaluated the effectiveness of oestradiol valerate/dienogest (E2V/DNG) for treating heavy or prolonged menstrual bleeding in women without underlying health issues, using data from two similar double-blind trials.
- After six months, women taking E2V/DNG experienced an 88% reduction in menstrual blood loss compared to just 24% in those on placebo, with the most significant improvement noted after the first withdrawal bleed.
- The findings concluded that E2V/DNG significantly outperformed placebo in reducing menstrual blood loss, and this effect started quickly and continued to improve over time.
Article Abstract
Objectives: To evaluate the efficacy of oestradiol valerate/dienogest (E2V/DNG) for the treatment of heavy and/or prolonged menstrual bleeding without organic pathology based on the analysis of data from two identically designed double-blind, randomised studies.
Methods: Women aged ≥ 18 years with heavy and/or prolonged menstrual bleeding were randomised to E2V/DNG (n = 269) or placebo (n = 152) for 196 days. Objective changes in menstrual blood loss (MBL) volume were assessed using the alkaline haematin method.
Results: After six months of treatment, median MBL decreased by 88% with E2V/DNG compared with 24% with placebo. The greatest reduction was achieved at the first withdrawal bleed after treatment initiation and it was sustained with no loss of effect throughout treatment.
Conclusion: E2V/DNG was more effective than placebo in reducing MBL in women with heavy and/or prolonged menstrual bleeding without organic pathology. The reduction was largely achieved as early as the first withdrawal bleed, with further gradual improvement throughout treatment.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3154543 | PMC |
| http://dx.doi.org/10.3109/13625187.2011.591456 | DOI Listing |
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