A multiplexed screening methodology for the rapid development of antifouling polymer surfaces is presented. An array of protein resistant polymer layers with high grafting (>100 mg m(-2)) were polymerized on optically encoded particles. Multiplexed analysis showed a 97% reduction in nonspecific protein adsorption for all polymer layers created.
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http://dx.doi.org/10.1039/c1cc13571f | DOI Listing |
J Colloid Interface Sci
December 2024
School of Engineering and Materials Science, Queen Mary University of London, Mile End Road, London E1 4NS, United Kingdom. Electronic address:
Understanding the architecture and mechanism of assembly of polyelectrolyte-nucleic acid complexes is critical to the rational design of their performance for gene delivery. Surface-initiated polymer brushes were recently found to be particularly effective at delivering oligonucleotides and maintaining high knock down efficiencies for prolonged periods of time, in highly proliferative cells. However, what distinguishes their binding capacity for oligonucleotides from that of larger therapeutic macromolecules remains unknown.
View Article and Find Full Text PDFEnviron Sci Technol
January 2025
Department of Civil and Environmental Engineering, The Hong Kong Polytechnic University, Kowloon, Hong Kong 999077, China.
Polyelectrolyte multilayer (PEM) membranes, with advantageous features of versatile chemistry and structures, are driving the development of advanced nanofiltration (NF) membranes with exceptional performance. While developing a printing method holds great promise for the eventual mass production of these membranes, reports on the printing method and the underlying mechanisms of membrane formation are currently scarce. Herein, we develop an aerosol-assisted printing (AAP) system for fabricating PEM NF membranes with highly tunable separation characteristics.
View Article and Find Full Text PDFACS Nano
January 2025
Key Laboratory of New Membrane Materials, Ministry of Industry and Information Technology, School of Environmental and Biological Engineering, Nanjing University of Science and Technology, Nanjing 210094, P. R. China.
Thermally driven membrane desalination processes have garnered significant interest for their potential in the treatment of hypersaline wastewater. However, achieving high rejection rates for volatiles while maintaining a high water flux remains a considerable challenge. Herein, we propose a thermo-osmosis-evaporation (TOE) system that utilizes molecular intercalation-regulated graphene oxide (GO) as the thermo-osmotic selective permeation layer, positioned on a hydrophobic poly(vinylidene fluoride) fibrous membrane serving as the thermo-evaporation layer.
View Article and Find Full Text PDFNat Chem
January 2025
State Key Laboratory of Advanced Drug Delivery and Release Systems, Liangzhu Laboratory, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, China.
Vesicles play critical roles in cellular materials storage and signal transportation, even in the formation of organelles and cells. Natural vesicles are composed of a lipid layer that forms a membrane for the enclosure of substances inside. Here we report a coacervate vesicle formed by the liquid-liquid phase separation of cholesterol-modified DNA and histones.
View Article and Find Full Text PDFACS Appl Bio Mater
January 2025
Polymers for Health and Biomaterials, IBMM UMR 5247, CNRS, ENSCM, University of Montpellier, 34090 Montpellier, France.
With a prevalence of over 90% in people over 50, intervertebral disc degeneration (IVDD) is a major health concern. This weakening of the intervertebral discs can lead to herniation, where the nucleus pulpus (NP) leaks through the surrounding Annulus Fibrosus (AF). Considering the limited self-healing capacity of AF tissue, an implant is needed to restore its architecture and function.
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