The development of a reaction for detecting the presence/absence of one methyl group in a long DNA strand is a chemically and biologically challenging research subject. A newly designed chemical assay on a chip for the typing of DNA methylation has been developed. A methylation-detection probe fixed at the bottom of microwells was crosslinked with methylated DNA mediated by osmium complexation and contributes to selective amplification of methylated DNA.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3136155 | PMC |
| http://dx.doi.org/10.4061/2011/480570 | DOI Listing |
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