An accurate understanding of the mechanisms underlying an individual's response to rt-PA treatment is critical to improve stroke patients' management. We thus reviewed the literature in order to identify biochemical and genetic factors that have been associated with safety and efficacy of rt-PA administration after stroke.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3137952PMC
http://dx.doi.org/10.4061/2011/182783DOI Listing

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