AI Article Synopsis
- The study focused on the time it takes for peak dilation of the brachial artery in youth after administering sublingual nitroglycerin (NTG) and found that peak dilation occurs around 4-5 minutes.
- Measurements were taken from 198 healthy youths aged 6-18, showing that the time to peak endothelium-independent dilation (EID) was 268 seconds post-NTG, with no significant difference between males and females.
- Significant differences in EID were observed at different time points (3, 4, and 5 minutes), highlighting the need to measure EID up to 5 minutes after NTG administration in young individuals.
Article Abstract
Peak brachial artery dilation post-nitroglycerin (NTG) administration occurs between 3 and 5 min in adults. The purpose of this study was to identify the time to peak dilation response to sublingual NTG (0·3 mg) in youth. Endothelium-independent dilation (EID) was measured in 198 healthy (113 males, 85 females) youth (6-18 years) via ultrasound imaging of the brachial artery following NTG administration. Time to peak EID was 268 s following NTG administration, with no significant (P = 0·6) difference between males and females. There was a significant (P<0·001) difference between EID post-NTG at the 3 versus 4 min, 4 versus 5-min, and 3 versus 5 min time points. Peak EID (males: 24·8 ± 0·5 versus females: 25·3 ± 0·6%, P = 0·6) was not significantly different after accounting for baseline diameter. Peak response to NTG administration occurs between 4 and 5 min. The results demonstrate the importance of measuring EID up to 5-min post-NTG administration in youth.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3718304 | PMC |
| http://dx.doi.org/10.1111/j.1475-097X.2011.01030.x | DOI Listing |
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