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http://dx.doi.org/10.1111/j.1365-2230.2011.04027.x | DOI Listing |
BMC Med Genomics
November 2024
Department of Hematology, Guangzhou First People's Hospital, Guangzhou, 510080, China.
We report a case of early-onset hereditary thrombotic thrombocytopenic purpura in a 16-year-old girl who suffered from thrombocytopenia and was misdiagnosed with immune thrombocytopenia for years until two failed gestations finally revealed the underlying cause. The novel compound heterozygous mutation c.2865G > A:p.
View Article and Find Full Text PDFJ Thromb Haemost
December 2024
Department of Pathology and Translational Pathobiology, Louisiana State University Health Sciences Center-Shreveport, Shreveport, Louisiana, USA. Electronic address:
Background: Patients with metabolic dysfunction-associated steatohepatitis (MASH) are at an increased risk of developing venous thromboembolic events, including deep vein thrombosis (DVT). To date, the study of DVT in MASH has been hampered by the lack of reliable models that mimic the pathologic aspects of human disease.
Objectives: To evaluate DVT severity and hypercoagulability in murine and human MASH.
J Thromb Haemost
December 2024
Department of Molecular Pathogenesis, National Cerebral and Cardiovascular Center, Suita, Japan. Electronic address:
Background: Protein S (PS) is an anticoagulant that functions as a cofactor for activated protein C and the tissue factor pathway inhibitor. PS deficiency is a risk factor for venous thromboembolism. PS activity is commonly measured using clot-based assays involving fibrin and thrombin production, but improvements are needed.
View Article and Find Full Text PDFJ Assoc Physicians India
April 2024
Physician, Department of General Medicine, Peerless Hospital, Kolkata, West Bengal, India.
History And Examination: A 21-year-old female patient presented to us with severe low back pain for 4 months. On examination, patient was afebrile, with severe pallor, and tenderness in both sacroiliac (SI) joints. Patient was being admitted and evaluated, and during the course of evaluation, developed severe headache, which was severe in intensity and associated with nausea and projectile vomiting.
View Article and Find Full Text PDFMedicine (Baltimore)
April 2024
Department of Neurology, Xiangya Hospital, Central South University, Changsha, People's Republic of China.
Rationale: White matter lesions (WMLs) are structural changes in the brain that manifest as demyelination in the central nervous system pathologically. Vasogenic WMLs are the most prevalent type, primarily associated with advanced age and cerebrovascular risk factors. Conversely, immunogenic WMLs, typified by multiple sclerosis (MS), are more frequently observed in younger patients.
View Article and Find Full Text PDFEnter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!