AI Article Synopsis
- Chronic idiopathic urticaria (CIU) is a long-lasting skin condition with no clear cause, typically treated with antihistamines and steroids, but mesalazine might be a promising alternative due to its anti-inflammatory effects.
- In a study involving 33 CIU patients, mesalazine was given in increasing doses, and the impact on their quality of life and symptoms was assessed over 8 weeks.
- Results showed that 66% of patients experienced improved quality of life and over half reported symptom relief, with treatment success linked inversely to the disease's duration, suggesting mesalazine is a viable option for managing CIU.
Article Abstract
Background: Chronic idiopathic urticaria (CIU), a debilitating condition, is defined as having urticaria for at least 6 weeks without any obvious cause. Antihistamines and steroids are popular treatments, but other alternatives have been evaluated. Mesalazine may be effective in CIU according to its anti-inflammatory properties via inhibition of 5-lipoxygenase, cycloxygenases, nuclear factor-kappa B activation, T lymphocyte proliferation and antigen stimulated histamine release.
Methods: Mesalazine was administered to 33 patients with CIU, starting at 500 mg/day with weekly incremental dosing to a total of 1 g/day. The patients' dermatology life quality index (DLQI) and symptom scores were recorded before and after 8 weeks of treatment. Screening laboratory tests before and during treatment period were performed.
Results: Mesalazine induced a statistically significant decrease in DLQI in 22 (66%) of 33 patients. It is also effective in reducing symptom score in at least half of the patients. The success of treatment was not related to age, sex, drug history and atopy, but was related to duration of the disease in reverse.
Conclusions: Mesalazine seems to be a safe and effective therapy for CIU in reducing DLQI and symptoms.
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| http://dx.doi.org/10.3109/09546634.2011.565015 | DOI Listing |
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