AI Article Synopsis
- Four new amino acid derivatives called herdmanines A-D were discovered in the marine ascidian Herdmania momus.
- Herdmanines A-C include a rare form of arginine (D-form).
- Compounds 3 and 4 showed moderate ability to reduce nitric oxide production and inhibited the expression of specific pro-inflammatory cytokines like TNF-α, IL-1β, and IL-6.
Article Abstract
Four new amino acid derivatives, herdmanines A-D (1-4), were isolated from the marine ascidian Herdmania momus. Herdmanines A-C contain the unusual D-form of arginine. Compounds 3 and 4 had a moderate suppressive effect on the production of NO, with IC₅₀ values of 96 and 9 μM, respectively. These compounds were found to inhibit the mRNA expression of iNOS. The inhibitory activities on the production and mRNA expression of pro-inflammatory cytokines such as TNF-α, IL-1β, and IL-6 were evaluated.
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| http://dx.doi.org/10.1021/np200397g | DOI Listing |
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