Mast cells as the body's main immune cells, not only involved in allergic, inflammatory response, but also related to a lot of physiological and pathological processes. Its differentiation, maturation, activation and media release are in strict regulation and control. The in-depth study of mast cells not only allows us to understand the mechanism of allergy, inflammation and autoimmune diseases more thoroughly, but also provide us some valuable reference about the prevention and treatment of such diseases.
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Department of Translational Biomedicine and Neuroscience, University of Bari Medical School, Bari, Italy. Electronic address:
Mast cells exert multiple roles beyond their classical role in IgE-mediated allergic reactions. These cells secrete pro-inflammatory and anti-inflammatory agents and change from protective immune cells to pro-inflammatory cells, capable of influencing the progression of different pathological conditions, including tumors, in which they exert anti-tumorigenic and pro-tumorigenic roles. In this context, this article analyzes the potential role played by mast cell-derived proteases in tumor progression and more specifically in driving metastatic process and the potential therapeutic approaches that inhibiting the activation of these cells could help faith cancer spreading.
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