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Adjuvant Chemotherapy Improves Survival for Children With Massive Choroidal Invasion of Retinoblastoma.
Invest Ophthalmol Vis Sci
August 2023
Department of Ophthalmology, Hospital for Sick Children, Toronto, Canada.
Purpose: The purpose of this study was to investigate the effect of adjuvant chemotherapy on outcomes of children with massive choroidal invasion (MCI).
Methods: In this study, we reviewed the 5-year relapse-free survival (RFS) and overall survival (OS) of children diagnosed with MCI, managed with or without adjuvant chemotherapy. Excluded were children with additional other high-risk features (post-laminar optic nerve invasion, scleral invasion, or overt extraocular disease).
Impact of Systemic Chemotherapy and Delayed Enucleation on Survival of Children with Advanced Intraocular Retinoblastoma.
Ophthalmol Retina
June 2020
Department of Ophthalmology, Hospital for Sick Children, Toronto, Canada; Krembil Research Institute, Toronto, Canada; Techna Institute, Toronto, Canada. Electronic address:
Purpose: Primary enucleation is a well-established method to achieve cure for advanced intraocular retinoblastoma. Recent treatment advances have induced a trend toward trial eye salvage using chemotherapy or other modalities. We investigated how pre-enucleation/postenucleation systemic chemotherapy and the resulting delayed enucleation affect patient survival after failed trial eye salvage.
View Article and Find Full Text PDF[Retinoblastoma spontaneous regression: clinical and histopathologic analysis].
Zhonghua Yan Ke Za Zhi
October 2014
Beijing Institute of Ophthalmology, Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing Ophthalmology & Visual Sciences Key Laboratory, Beijing 100005, China.
Objective: To analyze the clinicopathologic characteristics of retinoblastoma spontaneous regression.
Methods: Retrospective case series study. The clinic and pathologic data of 52 cases of retinoblastoma spontaneous regression were analyzed retrospectively.
Impact of chemoreduction for conservative therapy for retinoblastoma in Argentina.
Pediatr Blood Cancer
May 2014
Service of Hemato-Oncology, Hospital JP Garrahan, Buenos Aires, Argentina.
Background: Few studies were reported from developing countries regarding patient outcome and ocular survival in children with bilateral retinoblastoma treated with chemoreduction compared to external beam radiotherapy (EBRT).
Procedure: We undertook a retrospective study of three treatment eras: (1) (1988-1995) n = 68 when EBRT was used as primary conservative therapy; (2) (1995-2003) n = 46 when carboplatin-based systemic chemoreduction was introduced and (3) (2003-2009) (n = 83) when additional periocular chemotherapy was added for advanced tumors and pre-enucleation chemotherapy was given for those with massive buphthalmia.
Results: The probability of 5-year disease-free survival was 0.
Retinoblastoma presenting with orbital cellulitis.
J AAPOS
June 2013
Department of Vitreo-Retinal Services, Sankara Nethralaya, Nungambakkam, Chennai, Tamil Nadu, India.
Purpose: To study the effectiveness of pre-enucleation steroids in reducing inflammation in patients with retinoblastoma presenting as orbital cellulitis.
Methods: Medical records of consecutive retinoblastoma patients presenting at a single tertiary eye care center during a period of 3 years were retrospectively reviewed. For those who presented with orbital cellulitis, clinical, radiological, and histopathological variables were assessed.
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