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Detection of synergy using the combination of polymyxin B with either meropenem or rifampin against carbapenemase-producing Klebsiella pneumoniae. | LitMetric
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Detection of synergy using the combination of polymyxin B with either meropenem or rifampin against carbapenemase-producing Klebsiella pneumoniae.

George A Pankey Deborah S Ashcraft

Diagn Microbiol Infect Dis

Infectious Disease Research, Ochsner Clinic Foundation, New Orleans, LA 70121, USA.

Published: August 2011

Polymyxin B (PB) plus meropenem (MER) or rifampin (RIF) was tested by Etest® method and time-kill assay (TKA) against 14 genetically unique clinical Klebsiella pneumoniae carbapenemase-producing K. pneumoniae. PB + MER: Etest, 43% synergy; TKA, 64% synergy. Concordance between methods was 79%. For PB + RIF: Etest, 21% synergy; TKA, 100% synergy. Concordance between methods was 21%.

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http://dx.doi.org/10.1016/j.diagmicrobio.2011.05.003DOI Listing

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