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Novel imidazo[1,2-a]pyridine based inhibitors of the IGF-1 receptor tyrosine kinase: optimization of the aniline. | LitMetric
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Novel imidazo[1,2-a]pyridine based inhibitors of the IGF-1 receptor tyrosine kinase: optimization of the aniline.

Richard Ducray Clifford D Jones Frederic H Jung Iain Simpson Jon Curwen Martin Pass

Bioorg Med Chem Lett

AstraZeneca, Oncology Innovative Medicines, Centre de recherches, Z.I. Pompelle, 51689 Reims Cedex 2, France.

Published: August 2011

Following the discovery of imidazopyridine 1 as a potent IGF-1R tyrosine kinase inhibitor, the aniline part has been modified with the aim to optimize the properties of this series. The structure-activity relationships against IGF-1R kinase activity as well as inhibition of the hERG ion channel are discussed.

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http://dx.doi.org/10.1016/j.bmcl.2011.06.090DOI Listing

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