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Dexamethasone intravitreal implant in the treatment of macular edema secondary to necrotizing retinitis.
Eur J Ophthalmol
November 2024
Department of Rheumatology, Albacete University Hospital, Albacete, Spain.
Article Synopsis
- * All patients were initially treated with antiviral medication, but two needed additional surgical intervention due to complications. After the infections were controlled, they developed resistant macular edema, which was treated with a sustained-release dexamethasone implant.
- * The treatment led to significant improvement in both retinal edema and visual acuity, with no reactivation of the virus or major side effects over a two-year period, suggesting that this implant could be a viable option for similar cases.
Efficacy and Safety of Amenamevir, a Helicase-Primase Inhibitor for the Treatment of Acyclovir-Resistant Herpes Simplex Virus 1 Keratitis.
Cornea
January 2025
Service d'Ophtalmologie, Assistance Publique Hôpitaux de Paris (AP-HP), Université Paris-Saclay. Centre de Référence pour les maladies rares en ophtalmologie (OPHTARA), Le Kremlin-Bicêtre, France.
Article Synopsis
- The study aimed to evaluate the effectiveness and tolerance of amenamevir (AMNV) in treating recalcitrant herpes simplex keratitis (HSK) caused by acyclovir-resistant herpes simplex virus 1 strains.
- Six patients were analyzed retrospectively after failing traditional antiviral treatments, focusing on recurrence rates and visual acuity during AMNV therapy.
- Results showed that 66% of patients did not have any recurrences on AMNV, leading to a significant reduction in HSK episodes and some improvement in vision, although the latter was not statistically significant likely due to the small sample size.
Effectiveness of Photobiomodulation in Reducing Pain of Oral Mucosal Diseases: A Case Series.
Int Med Case Rep J
July 2023
Oral Medicine Department, Faculty of Dentistry, Universitas Padjadjaran, Bandung, Indonesia.
Introduction: Pain management becomes important in the treatment of oral mucosal diseases since it can impair the quality of life. Photobiomodulation (PBM) as an alternative therapy, has potency in reducing pain through several mechanisms targeting peripheral nerves in the target tissue.
Purpose: To discuss the effectiveness of PBM in the management of four cases of oral mucosal diseases.
Atypical Cutaneous Viral Infections Reveal an Inborn Error of Immunity in 8 Patients.
Microorganisms
May 2023
Laboratory of Clinical Immunology-Inflammation and Allergy LICIA, Faculty of Medicine and Pharmacy, Hassan II University, Casablanca 20250, Morocco.
Article Synopsis
- A study conducted at Ibn Rochd University Hospital-Casablanca from 2017 to 2021 found that unusual viral skin infections were often the first signs of inborn errors of immunity in children, affecting 1.3% of patients with suspected IEI.
- The research involved 591 newly diagnosed patients, identifying specific genetic deficiencies like GATA2, STK4, and COPA in some, linked to chronic or resistant viral skin infections.
- The study emphasizes the importance of recognizing these skin infections as potential indicators of underlying immunological issues, which could improve diagnosis and treatment for affected children and their families.
Microbial Keratitis following Self-Retained Cryopreserved Amniotic Membrane.
Case Rep Ophthalmol
September 2022
aAnterior Segment Division, King Khaled Eye Specialist Hospital, Riyadh, Saudi Arabia.
The aim of this study was to report a severe case of mixed fungal and bacterial microbial keratitis following implantation of a self-retained cryopreserved amniotic membrane, PROKERA® SLIM (Bio-Tissue, Inc) in a patient with history of neurotrophic ulcer secondary to herpetic epithelial keratitis. Despite maximally tolerated topical and systemic therapy, the patient's eye continued to deteriorate and eventually required evisceration. PROKERA implantation might be associated with severe recalcitrant microbial keratitis.
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