AI Article Synopsis
- Eight new linear polyacetylene glucosides (1-8) and three known polyacetylenes (9-11) were identified from the florets of Carthamus tinctorius L.
- Their structures were determined using spectroscopic methods and chemical analysis, with the configurations of compounds 3-9 confirmed through a specific circular dichroism method.
- All isolated compounds were tested for their ability to inhibit LPS-induced NO production in murine macrophages, showing only weak activity at a concentration of 1×10(-5)M.
Article Abstract
Eight new linear polyacetylene glucosides (1-8), containing two C(10)-, one C(13)- and five C(14)-acetylenes, together with three known polyacetylenes (9-11) were isolated from the florets of Carthamus tinctorius L. Their structures were elucidated by means of spectroscopic methods and chemical evidence. The absolute configurations of compounds 3-9 were confirmed by Snatzke and Gerards's method, observing the induced circular dichroism after addition of dirhodium tetrakis (trifluoroacetate) [Rh(2)(OCOCF(3))(4)] in CHCl(3). All the isolated compounds (1-11) were also tested for inhibitory activities against LPS-induced NO production in murine macrophages and just showed weak activities at concentrations of 1×10(-5)M.
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| http://dx.doi.org/10.1016/j.carres.2011.06.015 | DOI Listing |
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