AI Article Synopsis
- Bile duct injury (BDI) during surgeries can lead to severe complications, with some patients developing end-stage liver disease (ESLD) requiring liver transplants (LT).
- A national survey in Argentina revealed that from 1990 to 2009, the percentage of LTs performed due to BDI steadily decreased, with a mean age of patients being 45.7 years, mostly occurring during cholecystectomy procedures.
- The study found that while LT is less frequently utilized for BDI over time, it remains a viable option for select patients, particularly those facing acute liver failure or ESLD, with survival rates showing declines over the years.
Article Abstract
Background: Bile duct injury (BDI) is a severe complication that may arise during the surgical treatment of benign disease and a few patients will develop end-stage liver disease (ESLD) requiring a liver transplant (LT).
Objective: Analyse the experience using LT as a definitive treatment of BDI in Argentina.
Patients And Methods: A national survey regarding the experience of LT for BDI.
Results: Sixteen out 18 centres reported a total of 19 patients. The percentage of LT for BDI from the total number of LT per period was: 1990-94 = 3.1%, 1995-99 = 1.6%, 2000-04 = 0.7% and 2005-09 = 0.2% (P < 0.001). The mean age was 45.7 ± 10.3 years (range 26-62) and 10 patients were female. The BDI occurred during cholecystectomy in 16 and 7 had vascular injuries. One patient presented with acute liver failure and the others with chronic ESLD. The median time between BDI and LT was 71 months (range 0.2-157). The mean follow-up was 8.3 years (10 months to 16.4 years). Survival at 1, 3, 5 and 10 years was 73%, 68%, 68% and 45%, respectively.
Conclusions: The use of LT for the treatment of BDI declined over the review period. LT plays a role in selected cases in patients with acute liver failure and ESLD.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3163276 | PMC |
| http://dx.doi.org/10.1111/j.1477-2574.2011.00322.x | DOI Listing |
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