A concise, diastereoselective total synthesis of (±)-cortistatin J has been completed in 20 steps from furan. Key steps include an intramolecular [4 + 3] cyclization of a disubstituted furan with a (Z)-2-(trialkylsilyloxy)-2-enal to construct the tetracyclic core and a (Z)-vinylsilane/iminium ion cyclization to form the A ring.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3154988 | PMC |
| http://dx.doi.org/10.1021/ja206138d | DOI Listing |
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