Objective: To study the changes of mucosa irritation of crude and processed Radix Phytolaccae.

Method: Gastrointestinal experiments on rats and mice and the rabbits' eyes irritation experiments were applied to investigate the changes of mucosa irritation of crude and processed Radix Phytolaccae.

Result: The mucosa irritation of processed Radix Phytolaccae decreased obviously compared to crude one.

Conclusion: After being processed with vinegar, the mucosa irritation on Radix Phytolaccae decreased obviously.

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