Conclusive evidence has been furnished that the beta 2-adrenoceptor density in circulating lymphocytes is related to that of beta 2-adrenoceptors in tissues from the same subjects. This study was designed to evaluate the effect of fetal hypoxia on lymphocyte beta 2-adrenoceptor density. The material consisted of 8 hypoxic newborns, 4 delivered by vacuum extraction and 4 by Caesarean section, after approximately 10 h parturition. The control group consisted of 8 vaginally delivered newborns without hypoxia. Umbilical plasma adrenaline and noradrenaline were significantly elevated in the hypoxic newborns. Their lymphocyte beta 2-adrenoceptor density was lower (p less than 0.01) than that in the controls. A plausible explanation for this finding might be downregulation of beta 2-adrenoceptors because of elevated plasma catecholamine level.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1159/000293246 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Influence of acepromazine on the cardiovascular effects of dobutamine in isoflurane-anaesthetised horses premedicated with romifidine.
Vet Anaesth Analg
January 2025
School of Veterinary Medicine, Murdoch University, Perth, Western Australia, Australia.
Objective: To explore the influence of acepromazine on the cardiovascular effects of dobutamine in isoflurane-anaesthetised horses premedicated with romifidine.
Study Design: Prospective randomised clinical trial.
Animals: A total of 18 horses undergoing elective arthroscopy were enrolled, of which 12 horses requiring dobutamine were included.
Channeling Relaxation through Multiple Means: TMEM16A Antagonism for Asthma.
Am J Respir Cell Mol Biol
November 2024
Thomas Jefferson University, Medicine, Philadelphia, Pennsylvania, United States;
TMEM16A Antagonism: Therapeutic Potential with Desensitization of β-agonist Responsiveness in Asthma.
Am J Respir Cell Mol Biol
November 2024
Columbia University, Anesthesiology, New York, New York, United States;
The efficacy of β-agonists in asthma is severely limited by β-adrenoceptor desensitization which results in poorly managed symptoms and refractory bronchoconstriction. Thus, there is a need to identify novel therapeutic pathways and to clarify the relationship between novel therapeutics and functional β-adrenoceptor responsiveness. We have previously demonstrated that acute antagonism of the calcium activated chloride channel, transmembrane member 16A (TMEM16A), relaxes airway smooth muscle (ASM).
View Article and Find Full Text PDFThe Mechanism Involved in the Inhibition of Resveratrol and Genistein on the Contractility of Isolated Rat Uterus Smooth Muscle.
Nutrients
October 2024
Department of Physiology, College of Basic Medicine, Lanzhou University, Lanzhou 730000, China.
Article Synopsis
- This study investigated how phytoestrogens resveratrol (RES) and genistein (GEN) affect uterine muscle contractions in rats, focusing on both spontaneous and stimulated contractions.
- Both RES and GEN were found to inhibit contractions in a dose-dependent manner, and their effects were reduced when certain blockers and inhibitors were introduced, suggesting specific mechanisms at play.
- The findings indicate that RES and GEN not only reduced contractions from various stimuli but also impacted calcium responses, highlighting their potential role in regulating uterine smooth muscle activity.
Left ventricular systolic function after inhalation of beta-2 agonists in healthy athletes.
Sci Rep
October 2024
Division of Sports and Rehabilitation Medicine, Center of Internal Medicine, Ulm University Hospital, Leimgrubenweg 14, 80975, Ulm, Germany.
Inhaled beta-2 adrenoceptor agonists (iβ2A) are routinely used as bronchodilators in the treatment of asthma. However, their cardiac effects in athletes are scarcely examined. Thus, the aim of this study was to evaluate the effects of iβ2A on left ventricular (LV) systolic function (SF) by echocardiography in healthy, non-asthmatic female and male endurance athletes.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!