AI Article Synopsis
- The study aims to explore the link between Alzheimer's disease (AD) and primary open-angle glaucoma (POAG) through a comprehensive review of existing research.
- The findings show that while many studies suggest a strong correlation between AD and POAG, there are also conflicting results, indicating that the relationship is still not fully understood.
- The authors call for more extensive research focusing on genetic factors and large-scale studies, and they suggest that current evidence warrants increased clinical awareness of the potential overlap between AD and glaucoma in affected patients.
Article Abstract
Aim: To present, through a thorough literature research, current and older scientific efforts to investigate the putative association between Alzheimer's disease (AD) and glaucoma, especially primary open-angle glaucoma (POAG).
Methods: We included in our review article epidemiological, experimental and clinical laboratory studies.
Results: While many authors support the existence of a strong correlation between the AD and POAG, based on epidemiological, genetic and immunohistochemical data, others present contradictory results, leaving the issue unresolved.
Conclusion: Further research, probably targeted towards genetic parameters and based on large, multicenter studies has yet to be conducted. It is the authors' opinion however, that the existing data already justify the need for at least some degree of elevated clinical alertness for the occurrence of AD in patients with glaucoma and of glaucoma in patients with AD.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3133006 | PMC |
| http://dx.doi.org/10.2147/OPTH.S22485 | DOI Listing |
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