[Clinico-genealogical study of Alzheimer's disease].

A ++clinico-genealogical study of Alzheimer's disease (AD) was carried out on a material of 64 families of AD probands. Among the families examined, 21 families with hereditary aggravation, 17 sporadic and 26 conventionally sporadic families were distinguished. Risk for AD was established for relatives of the first degree kinship and a possible type of AD inheritance was defined. The differences were revealed with respect to the incidence of ++psycho-organic diseases in the first and second degree kinship relatives from the hereditary and sporadic families. Studies into the clinical pleomorphism of the Alzheimer's type dementias in hereditary cases enabled one to establish the genetically determined signs and the signs reflecting the environmental effects. The predictor signs (the premorbid characteristic traits and characteristics of the mnemonic and intellectual activity) were distinguished, allowing one to forecast, in 80% of cases, a possibility of the development of the Alzheimer's type dementias in women coming from the families with hereditary aggravation.