Metformin-induced cholangiohepatitis.

BMJ Case Rep

Case Western Reserve University @ MetroHealth Medical Center, Hospital Medicine, 2500 MetroHealth Dr, Cleveland, Ohio, 44138, USA.

Published: July 2011

Drug-induced cholangiohepatitis accounts for 20-50% of non-viral chronic hepatitis cases. Metformin is the most commonly prescribed oral anti-diabetic drug from the biguanide class used in treatment of overweight and obese type 2 diabetes mellitus patients. Metformin-induced cholangiohepatitis with marked elevations in serum liver transaminases and intrahepatic cholestasis has been infrequently reported. Here, we report a case of acute cholangiohepatitis after initiation of metformin treatment.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3028181PMC
http://dx.doi.org/10.1136/bcr.09.2008.0950DOI Listing

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