3-Diazo-N-[(2S)-1-hy-droxy-propan-2-yl]-2-oxopropanamide.

Acta Crystallogr Sect E Struct Rep Online

Published: May 2011

AI Article Synopsis

Article Abstract

In the title compound, C(6)H(9)N(3)O(3), the 3-diazo-2-oxopropan-amide section of the mol-ecule is nearly planar, with a maximum deviation of 0.025 (1) Å from the mean plane of its constituent atoms. The diazo C=N=N angle is 178.0 (3)°. In the crystal, pairs of inter-molecular O-H⋯O and N-H⋯O hydrogen bonds link the mol-ecules into infinite double chains along the [100] direction. The double chains are additionally stabilized by weak C-H⋯O contacts with C⋯O distances of 3.039 (3) Å. Neighboring double chains in turn inter-act with each other through π-π stacking inter-actions [centroid-centroid distance of the 3-diazo-2-oxopropanamide units = 3.66 (6) Å] to form infinite stacks along the b axis. Mol-ecules from neighboring stacks inter-digitate with each other in the c-axis direction, thus leading to an inter-woven three-dimensional network held together by O-H⋯O, N-H⋯O and C-H⋯O inter-actions and π-π stacking.

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3089269PMC
http://dx.doi.org/10.1107/S1600536811014413DOI Listing

Publication Analysis

Top Keywords

double chains
12
o-h⋯o n-h⋯o
8
π-π stacking
8
3-diazo-n-[2s-1-hy-droxy-propan-2-yl]-2-oxopropanamide title
4
title compound
4
compound c6h9n3o3
4
c6h9n3o3 3-diazo-2-oxopropan-amide
4
3-diazo-2-oxopropan-amide mol-ecule
4
mol-ecule planar
4
planar maximum
4

Similar Publications

L-Threonine-Derived Biodegradable Polyurethane Nanoparticles for Sustained Carboplatin Release.

Pharmaceutics

December 2024

Department of Polymer Science and Engineering, Pusan National University, Busan 46241, Republic of Korea.

The use of polymeric nanoparticles (NPs) in drug delivery systems offers the advantages of enhancing drug efficacy and minimizing side effects; In this study, L-threonine polyurethane (LTPU) NPs have been fabricated by water-in-oil-in-water emulsion and solvent evaporation using biodegradable and biocompatible LTPU. This polymer was pre-synthesized through the use of an amino acid-based chain extender, desaminotyrosyl L-threonine hexyl ester (DLTHE), where urethane bonds are formed by poly(lactic acid)-poly(ethylene glycol)-poly(lactic acid) (PLA-PEG-PLA) triblock copolymer and 1,6-hexamethylene diisocyanate (HDI). LTPU is designed to be degraded by hydrolysis and enzymatic activity due to the presence of ester bonds and peptide bonds within the polymer backbone.

View Article and Find Full Text PDF

Role of miRNAs in Regulating Ascending Aortic Dilation in Bicuspid Aortic Valve Patients Operated for Aortic Stenosis.

Int J Mol Sci

January 2025

Research Direction, Instituto Nacional de Cardiología Ignacio Chávez, Juan Badiano No. 1, Col. Sección XVI, Mexico City 14080, Mexico.

Deregulation of micro-RNAs (miRNAs) may contribute to mechanisms of injury in the bicuspid aortic valve (BAV). Our objective was to investigate the expression of miRNAs in aortic tissue from patients who underwent aortic valve replacement for aortic stenosis and its relationship with aortic dilatation. The study included 78 patients, 40 with bicuspid aortic valve (BAV) and 38 with tricuspid aortic valve (TAV).

View Article and Find Full Text PDF

(1) Background: The incidence of gestational diabetes mellitus (GDM) is rising globally. The current evidence indicates that GDM, especially in conjunction with maternal overweight, can alter the composition of infants' gut microbiota, potentially increasing the risk of inflammatory diseases, metabolic disorders, and neurodevelopmental issues later in life. Probiotic supplantation early in life might establish eubiosis and mitigate future complications.

View Article and Find Full Text PDF

Genomic Landscape and Prediction of Udder Traits in Saanen Dairy Goats.

Animals (Basel)

January 2025

Key Laboratory of Animal Genetics, Breeding and Reproduction of Shaanxi Province, College of Animal Science and Technology, Northwest A&F University, Yangling 712100, China.

Goats are essential to the dairy industry in Shaanxi, China, with udder traits playing a critical role in determining milk production and economic value for breeding programs. However, the direct measurement of these traits in dairy goats is challenging and resource-intensive. This study leveraged genotyping imputation to explore the genetic parameters and architecture of udder traits and assess the efficiency of genomic prediction methods.

View Article and Find Full Text PDF

Background: Antimicrobial resistance remains a worldwide health problem with serious societal and economical repercussions. Multidrug resistant and Extended-Spectrum β-Lactamase producing-Enterobacterales (ESBL-E) are pathogens of critical public health priority that urgently require the research and development of new drugs. This study aims to determine the prevalence and characterize the genes conferring resistance to β-lactams among Escherichia coli and Klebsiella pneumoniae isolated from patients with urinary tract infections (UTIs) in the West region, Cameroon.

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!