Varenicline induces manic relapse in bipolar disorder.

Varenicline (Chantix) is commonly used to assist individuals with smoking cessation. This medication is known to affect mood and behavior. We report a patient with bipolar disorder who developed manic relapse after starting treatment with varenicline for tobacco dependence. Further research is necessary to establish the safety of using varenicline in individuals who have significant mental illness and want to stop smoking.