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Commentary on "Possible induction of acute disseminated encephalomyelitis (ADEM)-like demyelinating illness by intrathecal mesenchymal stem cell injection".
J Clin Neurosci
February 2013
Department of Medicine, Melbourne Brain Centre at the Royal Melbourne Hospital, University of Melbourne, Royal Parade, Parkville, Victoria 3050, Australia.
The case report that is the subject of this Commentary describes a 27-year-old woman, who, 3 months after a devastating low cervical myelitis, underwent intrathecal mesenchymal stem cell (MSC) infusions. Six hours after the third infusion, she became unconscious, febrile and cerebral MRI showed acute bitemporal and left cerebellar lesions, consistent with an acute disseminated encephalomyelitis. It is likely that this is the first reported patient with neuroinflammatory exacerbation after MSC therapy.
View Article and Find Full Text PDFLeucoencephalopathy with bitemporal lobe cysts in a child with developmental delay.
Sultan Qaboos Univ Med J
August 2007
Department of Genetics, College of Medicine and Health Sciences, Sultan Qaboos University Hospital, P. O. Box 35, Al-Khod 123, Muscat, Sultanate of Oman;
The predictive value of intraoperative electrocorticography in resections for limbic epilepsy associated with mesial temporal sclerosis.
Neurosurgery
February 1997
Department of Neurological Surgery, Columbia-Presbyterian Medical Center, New York, New York, USA.
Objective: Prior studies on the predictive value of intraoperative electrocorticography (ECoG) have been performed on heterogeneous groups of patients with both temporal and extratemporal interictal spikes, lesional and nonlesional pathological findings, and variably extensive resections by different surgeons.
Methods: We performed both pre- and postresection intraoperative ECoG on 29 consecutive patients with medial temporal lobe epilepsy (17 left-sided) who underwent standard nontailored resections by one surgeon (RRG). All patients had only temporal interictal spikes (six bitemporal) and mesial temporal sclerosis diagnosed by preoperative magnetic resonance imaging and confirmed by pathological examination of resected tissue.
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