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Ultrasensitive Detection of Circulating Plasma Cells Using Surface-Enhanced Raman Spectroscopy and Machine Learning for Multiple Myeloma Monitoring.
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Key Laboratory of OptoElectronic Science and Technology for Medicine of Ministry of Education, Fujian Provincial Key Laboratory of Photonics Technology, Fujian Normal University, Fuzhou, Fujian 350117, China.
Multiple myeloma is a hematologic malignancy characterized by the proliferation of abnormal plasma cells in the bone marrow. Despite therapeutic advancements, there remains a critical need for reliable, noninvasive methods to monitor multiple myeloma. Circulating plasma cells (CPCs) in peripheral blood are robust and independent prognostic markers, but their detection is challenging due to their low abundance.
View Article and Find Full Text PDFIntegration of Functional Materials in Photonic and Optoelectronic Technologies for Advanced Medical Diagnostics.
Biosensors (Basel)
January 2025
Department of Electronic Engineering, Gachon University, Seongnam 13120, Republic of Korea.
Integrating functional materials with photonic and optoelectronic technologies has revolutionized medical diagnostics, enhancing imaging and sensing capabilities. This review provides a comprehensive overview of recent innovations in functional materials, such as quantum dots, perovskites, plasmonic nanomaterials, and organic semiconductors, which have been instrumental in the development of diagnostic devices characterized by high sensitivity, specificity, and resolution. Their unique optical properties enable real-time monitoring of biological processes, advancing early disease detection and personalized treatment.
View Article and Find Full Text PDFTailored Colloidal Shapes in Precursor Solutions for Efficient Blade-Coated Perovskite Solar Modules.
Adv Mater
January 2025
Beijing National Laboratory for Molecular Science, CAS Key Laboratory of Green Printing, Institute of Chemistry, Chinese Academy of Sciences, Beijing, 100190, China.
Metal halide perovskite solar cells (PSCs) have emerged as one of the most promising candidates for next-generation photovoltaic technologies. However, perovskite films deposited by blade-coating usually exhibit inferior film morphology compared to those fabricated by spin-coating, which hinders the power conversion efficiency (PCE) and stability of the scalable perovskite solar modules (PSMs). Herein, ellipsoidal colloids are tailored in the perovskite precursor solution by incorporating perovskite colloids and polymer additives.
View Article and Find Full Text PDFCombining T cell receptor sequencing and transcriptomics to characterize tissue-resident T cells from human gut biopsies.
Biochem Biophys Res Commun
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Center for Regenerative Therapies Dresden, Faculty of Medicine, Technische Universität Dresden, Dresden, Germany; Medizinische Klinik und Poliklinik I, Universitätsklinikum Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany. Electronic address:
Gastrointestinal T cells (GI-T) play a critical role in mucosal immunity, balancing tolerance and pathogen defence. T cells recognize antigens via T cell receptors (TCRs). Next-generation sequencing (NGS) is utilized to analyse TCR repertoires in contexts such as health, haematological diseases, autoimmunity, and inflammation.
View Article and Find Full Text PDFCharacterization of Pediatric Extrathoracic Aerosol Deposition with Air-Jet Dry Powder Inhalers.
J Aerosol Sci
January 2025
Department of Mechanical and Nuclear Engineering, Virginia Commonwealth University, Richmond, VA.
The use of air-jet dry powder inhalers (DPIs) offers a number of advantages for the administration of pharmaceutical aerosols, including the ability to achieve highly efficient and potentially targeted aerosol delivery to the lungs of children using the oral or trans-nasal routes of administration. To better plan targeted lung delivery of pharmaceutical aerosols with these inhalers, more information is needed on the extrathoracic (ET) depositional loss in pediatric subjects when using relatively small (e.g.
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