Research was conducted into the influence of pharmaceutical excipients on model soft gel capsules filling containing ibuprofen. The HPLC method was employed to assess the changes of active substance content and level of impurities depending on excipients of soft gel capsule filling. HPLC analysis after 6 months stability tests was conducted and active substance content and the level of impurities were assessed in soft gelatin capsules to evaluate the influence of excipients of the shell on tested parameters. Obtained results were determining the purpose application of ibuprofen containing soft gelatin capsules and implementing new drug to the market.
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