Objective: The authors aimed to describe the atherosclerotic lesions of the cerebral arterioles as a substrate of their rupture and bleeding.
Methods: The study was performed on the brain of nine Caucasian fetal victims of intra- and periventricular hemorrhage, all grade IV, and nine control cases.
Results: In the nine victims of hemorrhage, the arteriolar wall structure was altered, focally transformed into a deposit of amorphous eosinophilic material. Such changes often affected the full thickness of the wall causing rupture and hemorrhage. In eight of these cases and in two victims of the control group, the mothers were heavy cigarette smokers (15-20 cigarettes/day) before and during pregnancy.
Conclusion: The authors conclude that intra- and periventricular hemorrhage can be ascribed to the toxic effects of prenatal absorption of nicotine.
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