AI Article Synopsis
- A LDL particle was modified with a GdDO3A-monoamide chelate that includes a long alkenyl anchor to improve imaging of atherosclerotic plaques.
- When this GdDO3A-OA compound was integrated into the lipid layer of LDL particles, it significantly increased the magnetic resonance imaging (MRI) signal for detecting atheroplaques.
- This advancement shows potential for better in vivo imaging of cardiovascular diseases in mouse models.
Article Abstract
A LDL particle functionalized with a GdDO3A-monoamide chelate with a long alkenyl anchor (GdDO3A-OA) was prepared for in vivo detection of atheroplaques. The GdDO3A-OA, when successfully intercalated into the lipid layer of LDL particles, led to a significant enhancement of magnetic resonance imaging signal intensity of atheroplaques in atherosclerosis mouse models.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1039/c1cc10924c | DOI Listing |
Publication Analysis
Top Keywords
mouse models
8
ldl-based nanoparticles
4
nanoparticles contrast
4
contrast enhanced
4
enhanced mri
4
mri atheroplaques
4
atheroplaques mouse
4
models ldl
4
ldl particle
4
particle functionalized
4
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!