Background: Agent-based simulation models can be used to explore the impact of policy and practice on drug use and related consequences. In a linked paper (Perez et al., 2011), we described SimAmph, an agent-based simulation model for exploring the use of psychostimulants and related harm amongst young Australians.
Methods: In this paper, we use the model to simulate the impact of two policy scenarios on engagement in drug use and experience of drug-related harm: (i) the use of passive-alert detection (PAD) dogs by police at public venues and (ii) the introduction of a mass-media drug prevention campaign.
Results: The findings of the first simulation suggest that only very high rates of detection by PAD dogs reduce the intensity of drug use, and that this decrease is driven mainly by a four-fold increase in negative health consequences as detection rates rise. In the second simulation, our modelling showed that the mass-media prevention campaign had little effect on the behaviour and experience of heavier drug users. However, it led to reductions in the prevalence of health-related conditions amongst moderate drug users and prevented them from becoming heavier users.
Conclusion: Agent-based modelling has great potential as a tool for exploring the reciprocal relationships between environments and individuals, and for highlighting how intended changes in one domain of a system may produce unintended consequences in other domains. The exploration of these linkages is important in an environment as complex as the drug policy and intervention arena.
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http://dx.doi.org/10.1016/j.drugpo.2011.05.018 | DOI Listing |
PNAS Nexus
January 2025
The Program for Experimental & Theoretical Modeling, Division of Hepatology, Department of Medicine, Stritch School of Medicine, Loyola University Chicago, Maywood, IL 60153, USA.
Global elimination of chronic hepatitis C (CHC) remains difficult without an effective vaccine. Since injection drug use is the leading cause of hepatitis C virus (HCV) transmission in Western Europe and North America, people who inject drugs (PWID) are an important population for testing HCV vaccine effectiveness in randomized-clinical trials (RCTs). However, RCTs in PWID are inherently challenging.
View Article and Find Full Text PDFCPT Pharmacometrics Syst Pharmacol
January 2025
Astellas Pharma Inc., Northbrook, Illinois, USA.
The antitumor efficacy of an intratumoral injection of a genetically engineered oncolytic vaccinia virus carrying human IL-7 and murine IL-12 genes (hIL-7/mIL-12-VV) was demonstrated in CT26.WT-bearing mice. In the CT26.
View Article and Find Full Text PDFPLoS Comput Biol
December 2024
Department of Physics, Ashoka University, Sonepat, Haryana, India.
BharatSim is an open-source agent-based modelling framework for the Indian population. It can simulate populations at multiple scales, from small communities to states. BharatSim uses a synthetic population created by applying statistical methods and machine learning algorithms to survey data from multiple sources, including the Census of India, the India Human Development Survey, the National Sample Survey, and the Gridded Population of the World.
View Article and Find Full Text PDFEntropy (Basel)
December 2024
Graduate School of Arts and Sciences, University of Tokyo, Tokyo 153-8902, Japan.
We study the emergence of agency from scratch by using Large Language Model (LLM)-based agents. In previous studies of LLM-based agents, each agent's characteristics, including personality and memory, have traditionally been predefined. We focused on how individuality, such as behavior, personality, and memory, can be differentiated from an undifferentiated state.
View Article and Find Full Text PDFEntropy (Basel)
December 2024
Institute for Physics, University of Greifswald, 17489 Greifswald, Germany.
We present the results from kinetic theory for a system of self-propelled particles with alignment interactions of higher-order symmetry, particularly nematic ones. To this end, we use the Landau equation approach, a systematic approximation to the BBGKY hierarchy for small effective couplings. Our calculations are presented in a pedagogical way with the explicit goal of serving as a tutorial from a physicists' perspective into applying kinetic theory ideas beyond mean-field to active matter systems with essentially no prerequisites and yield predictions without free parameters that are in quantitative agreement with direct agent-based simulations.
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